Gott D M, Griffiths L A
Xenobiotica. 1987 Apr;17(4):423-34. doi: 10.3109/00498258709043949.
Antibiotic pretreatment significantly altered metabolism of (+)-catechin (cyanidanol-3) in the rat, with decreases in both the urinary elimination of flavanol conjugates and of ring scission of the O-heterocyclic aglycone. The majority of the beta-glucuronidase(s) active in the degradation of flavanol conjugates is associated with the anaerobic microflora of the rat intestine. Ring scission is a minor reaction in vivo and appears to be due to anaerobic bacteria, although in vitro it is the major reaction and is promoted by both anaerobes and aerobes. The intestinal microflora are capable of demethylating the metabolite 3'-O-methyl-(+)-catechin in vivo; the major activity being associated with the aerobic microflora. Faecal elimination of unchanged (+)-catechin is of minor importance.
抗生素预处理显著改变了大鼠体内（+）-儿茶素（氰定醇-3）的代谢，导致黄烷醇共轭物的尿排泄量以及O-杂环苷元的环裂解均减少。参与黄烷醇共轭物降解的大多数β-葡萄糖醛酸酶与大鼠肠道的厌氧微生物群有关。环裂解在体内是次要反应，似乎是由厌氧菌引起的，尽管在体外它是主要反应，厌氧菌和好氧菌都能促进其发生。肠道微生物群能够在体内使代谢物3'-O-甲基-（+）-儿茶素去甲基化；主要活性与需氧微生物群有关。未改变的（+）-儿茶素经粪便排泄的重要性较小。
