Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Institute of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Andrology. 2022 Nov;10(8):1556-1566. doi: 10.1111/andr.13283. Epub 2022 Sep 11.
Several hematologic parameters have been shown to be strongly associated with cardiovascular disease, yet few studies were conducted to assess their relationship with atherogenic erectile dysfunction.
To find out the differences in hematological parameters between patients with atherogenic erectile dysfunction and healthy controls through as comprehensive a hematological examination as possible and try to assess and predict atherogenic erectile dysfunction using possible indicators.
We collected hematological parameters in detail from 105 healthy controls and 183 patients with erectile dysfunction (119 patients with atherogenic erectile dysfunction patients and 64 patients with venous erectile dysfunction) who were selected by nocturnal penile tumescence and rigidity and color duplex doppler ultrasound.
Statistically significant differences were found between the atherogenic erectile dysfunction and venous erectile dysfunction groups in platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, and mean platelet volume (all p < 0.01). When comparing atherogenic erectile dysfunction with the healthy population, we found statistically significant differences between the two groups in white blood cell, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, triglycerides, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, triglycerides, and high-density lipoprotein cholesterol, p < 0.01; white blood cell, p = 0.024; non-high-density lipoprotein cholesterol, p = 0.036). Receiver operator characteristic curve analysis showed that neutrophil to lymphocyte ratio and platelet to lymphocyte ratio had the highest diagnostic value (neutrophil to lymphocyte ratio: area under the curve = 0.810, p < 0.001, cut-off = 1.995; platelet to lymphocyte ratio: area under the curve = 0.782, p < 0.001, cut-off = 126.3).
Several hematological parameters (white blood cell, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, mean platelet volume, triglycerides, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol) can be considered markers of atherogenic erectile dysfunction, while these parameters were not significantly different in venous erectile dysfunction compared to healthy subjects. This suggests that hematological examinations may be a convenient and effective method to help evaluate and diagnose atherogenic erectile dysfunction.
多项血液学参数与心血管疾病密切相关，但很少有研究评估其与动脉粥样硬化性勃起功能障碍的关系。
通过尽可能全面的血液学检查，找出动脉粥样硬化性勃起功能障碍患者与健康对照者之间血液学参数的差异，并尝试使用可能的指标评估和预测动脉粥样硬化性勃起功能障碍。
我们详细收集了 105 名健康对照者和 183 名勃起功能障碍患者（119 名动脉粥样硬化性勃起功能障碍患者和 64 名静脉性勃起功能障碍患者）的血液学参数，这些患者是通过夜间阴茎勃起和硬度及彩色双功能超声多普勒检测筛选出来的。
在血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值和平均血小板体积方面，动脉粥样硬化性勃起功能障碍组与静脉性勃起功能障碍组之间存在统计学显著差异（均 P<0.01）。与健康人群相比，动脉粥样硬化性勃起功能障碍组与对照组之间在白细胞、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、平均血小板体积、三酰甘油、高密度脂蛋白胆固醇和非高密度脂蛋白胆固醇方面存在统计学显著差异（中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、平均血小板体积、三酰甘油和高密度脂蛋白胆固醇，P<0.01；白细胞，P=0.024；非高密度脂蛋白胆固醇，P=0.036）。受试者工作特征曲线分析显示，中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值具有最高的诊断价值（中性粒细胞与淋巴细胞比值：曲线下面积=0.810，P<0.001，截断值=1.995；血小板与淋巴细胞比值：曲线下面积=0.782，P<0.001，截断值=126.3）。
多项血液学参数（白细胞、血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值、平均血小板体积、三酰甘油、高密度脂蛋白胆固醇和非高密度脂蛋白胆固醇）可作为动脉粥样硬化性勃起功能障碍的标志物，而这些参数在静脉性勃起功能障碍与健康对照者之间无显著差异。这表明血液学检查可能是一种方便有效的方法，有助于评估和诊断动脉粥样硬化性勃起功能障碍。
