Gao Hui, Wu Xu, Zhang Yuyang, Liu Guodong, Zhang Xiansheng
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Institute of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Int J Impot Res. 2024 Aug 29. doi: 10.1038/s41443-024-00969-5.
Systemic immune inflammation index (SII) is a global parameter that comprehensively reflects body inflammation, this study aims to assess the correlation between this index and erectile dysfunction (ED). This cross-sectional study incorporated 164 ED patients and 95 healthy adult males. The collection of general demographic information and pertinent hematological data from the participants enabled the computation of corresponding SII values. Statistical analysis, encompassing descriptive statistics as well as normality and logistic regression analyses, was carried out employing SPSS version 26. The findings of the univariate analysis revealed a noteworthy distinction in triglyceride levels (TG) (P = 0.017) and SII (P < 0.001) between ED patients and the healthy population. Subsequent multivariate logistic regression analysis unveiled a significant association between SII (odd ratio (OR):1.012, 95% confidence interval (CI):1.008-1.015; P < 0.001) and the occurrence of ED. Since the impact value is not clearly visible, SII/100 is utilized to magnify the effect value one hundredfold. The regression analysis results indicate that the OR value of SII/100 is 3.171, and the 95% CI is 2.339-4.298 (P < 0.001). The Receiver Operating Characteristic (ROC) curve analysis ascertained an AUC of 0.863 (P < 0.001) for SII, with a determined cut-off value of 391.53(10/L), exhibiting a sensitivity of 81.7% and specificity of 83.2%. Moreover, when comparing patients with varying degrees of ED severity, both univariate (P < 0.001) and subsequent multivariate logistic regression analyses (OR: 1.007, 95% CI: 1.004-1.010; P < 0.001) underscored the significance of the SII value. At this point, SII/100 OR: 1.971, 95% CI: 1.508-2.576 (P < 0.001). The ROC curve analysis in this context demonstrated an AUC of 0.799 (P < 0.001), with a determined cut-off value of 746.63(10/L), featuring a sensitivity of 60.6% and specificity of 91.6%. These discerned outcomes affirm a correlation between SII and ED, establishing its potential not only in predicting the onset of ED but also in differentiating among various levels of ED severity.
全身免疫炎症指数（SII）是一个全面反映身体炎症的整体参数，本研究旨在评估该指数与勃起功能障碍（ED）之间的相关性。这项横断面研究纳入了164例ED患者和95名健康成年男性。收集参与者的一般人口统计学信息和相关血液学数据，以便计算相应的SII值。使用SPSS 26版进行了包括描述性统计以及正态性和逻辑回归分析在内的统计分析。单因素分析结果显示，ED患者与健康人群在甘油三酯水平（TG）（P = 0.017）和SII（P < 0.001）方面存在显著差异。随后的多因素逻辑回归分析揭示了SII（比值比（OR）：1.012，95%置信区间（CI）：1.008 - 1.015；P < 0.001）与ED发生之间存在显著关联。由于影响值不明显，故采用SII/100将效应值放大100倍。回归分析结果表明，SII/100的OR值为3.171，95% CI为2.339 - 4.298（P < 0.001）。受试者工作特征（ROC）曲线分析确定SII的曲线下面积（AUC）为0.863（P < 0.001），确定的截断值为391.53(10/L)，灵敏度为81.7%，特异性为83.2%。此外，在比较不同ED严重程度的患者时，单因素（P < 0.001）及随后的多因素逻辑回归分析（OR：1.007，95% CI：1.004 - 1.010；P < 0.001）均强调了SII值的重要性。此时，SII/100的OR为1.971，95% CI为1.508 - 2.576（P < 0.001）。在此背景下的ROC曲线分析显示AUC为0.799（P < 0.001），确定的截断值为746.63(10/L)，灵敏度为60.6%，特异性为91.6%。这些研究结果证实了SII与ED之间的相关性，表明其不仅在预测ED的发生方面具有潜力，而且在区分不同程度的ED严重程度方面也具有潜力。
