Department of Ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Medicine (Baltimore). 2022 Aug 26;101(34):e30068. doi: 10.1097/MD.0000000000030068.
Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive rod and cone photoreceptor degeneration. Changes in retinal vasculature have long been associated with RP. Optical coherence tomography angiography (OCTA) is a novel imaging technology that enables noninvasive visualization of the retinal and choroidal microvasculature. OCTA enables quantification of microvascular changes in the retinal capillary plexus and choriocapillaris, in addition to qualitative feature description. Therefore, OCTA has the potential to become an important tool for better understanding, early detection, progression, and treatment of RP. In this review, we focus on the applications of OCTA in clinical research on RP. We also discuss future improvements in the OCTA technology for RP management. We believe that the advancement of the OCTA technique will ultimately lead to a better understanding of RP and aid in the prevention of visual impairment.
色素性视网膜炎(RP)是一组以进行性视杆和视锥光感受器变性为特征的遗传性视网膜疾病。视网膜血管的变化很早就与 RP 有关。光学相干断层扫描血管造影术(OCTA)是一种新的成像技术,可以无创地观察视网膜和脉络膜的微血管。OCTA 可以定量分析视网膜毛细血管丛和脉络膜毛细血管的微血管变化,同时还可以进行定性特征描述。因此,OCTA 有可能成为更好地理解、早期发现、进展和治疗 RP 的重要工具。在这篇综述中,我们重点介绍了 OCTA 在 RP 临床研究中的应用。我们还讨论了 OCTA 技术在 RP 管理方面的未来改进。我们相信,OCTA 技术的进步最终将有助于更好地理解 RP,并有助于预防视力损害。