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14C标记的三甲胺及其氮氧化物在人体内的代谢

The metabolism of 14C-labelled trimethylamine and its N-oxide in man.

作者信息

Al-Waiz M, Mitchell S C, Idle J R, Smith R L

出版信息

Xenobiotica. 1987 May;17(5):551-8. doi: 10.3109/00498258709043962.

DOI:10.3109/00498258709043962
PMID:3604260
Abstract

The metabolism and elimination of 14C-labelled trimethylamine and its N-oxide (100 mg orally) were studied in three male volunteers. For both compounds the urine was the major route of elimination, with 95% of the administered 14C being voided in the first 24 h. No radioactivity was found in expired air. The majority (greater than 95%) of the urinary 14C from both compounds was excreted as trimethylamine N-oxide.

摘要

在三名男性志愿者中研究了14C标记的三甲胺及其N-氧化物(口服100毫克)的代谢和消除情况。对于这两种化合物,尿液是主要的消除途径,给药的14C中有95%在最初24小时内排出。呼出气体中未发现放射性。两种化合物的尿中14C大部分(超过95%)以三甲胺N-氧化物的形式排泄。

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