蛋白酶激活受体-1基因多态性在慢性阻塞性肺疾病易感性中的作用

Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease.

作者信息

Yun C M, Sang X Y

机构信息

Department of Senile Disease, Tai'an Central Hospital of Shandong Province, Tai'an, China

Department of Senile Disease, Tai'an Central Hospital of Shandong Province, Tai'an, China.

出版信息

Genet Mol Res. 2015 Oct 27;14(4):13215-20. doi: 10.4238/2015.October.26.18.

DOI:10.4238/2015.October.26.18

PMID:26535635

Abstract

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess the polymorphisms PAR1 IVS-14 A/T rs168753 and -506 I/D rs11267092. The frequency of the AA genotype in PAR1 IVS-14 A/T rs168753 was significantly higher than in the controls (χ(2) = 7.23, P = 0.03). By logistic regression analysis, we found that the AA genotype of PAR1 IVS-14 A/T rs168753 was associated with increased risk of COPD compared with the GG genotype. The adjusted OR (95%CI) was 2.00 (1.15-3.50) for the AA genotype. In conclusion, we found that the PAR1 IVS-14 A/T rs168753 polymorphism was associated with the development of COPD.

摘要

我们开展了一项病例对照研究，以调查PAR1基因多态性与慢性阻塞性肺疾病（COPD）发生之间的关联。在2012年3月至2014年3月期间，连续招募了总共270例COPD患者和270名对照受试者。采用聚合酶链反应-限制性片段长度多态性分析来评估PAR1 IVS-14 A/T rs168753和-506 I/D rs11267092的多态性。PAR1 IVS-14 A/T rs168753中AA基因型的频率显著高于对照组（χ(2)=7.23，P=0.03）。通过逻辑回归分析，我们发现与GG基因型相比，PAR1 IVS-14 A/T rs168753的AA基因型与COPD风险增加相关。AA基因型的校正OR（95%CI）为2.00（1.15 - 3.50）。总之，我们发现PAR1 IVS-14 A/T rs168753多态性与COPD的发生有关。