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肢体软组织肉瘤广泛切除的结果:一项回顾性分析。

Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis.

作者信息

Sheoran Ajay, Garg Abhishek, Yadav Umesh, Kundu Zile Singh, Sherawat Ravi, Singla Mohit, Nemani Mudit, Wason Deepender, Kulaar Harshdeep Singh, Singha Sabuj Baran

机构信息

Orthopaedics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, IND.

Orthopaedics, Positron Multispecialty Hospital, Rohtak, IND.

出版信息

Cureus. 2022 Jul 27;14(7):e27329. doi: 10.7759/cureus.27329. eCollection 2022 Jul.

Abstract

Background Soft-tissue sarcomas (STSs) are a rare heterogeneous group of tumors. Good functional results can be achieved with tumor excision in combination with suitable supplemental adjuvant therapies if needed. This study aimed to investigate the outcomes of wide resection of STS of the extremities. Methodology In this retrospective study, a total of 139 patients diagnosed with STS of the extremities by radiological and/or histopathological study/biopsy were included. All patients irrespective of metastasis were included. Results The mean age of the patients in our study was 43.5 ± 18.89 years. Overall, the mean tumor size was found to be 11.81 ± 6.218 cm. Malignant fibrous histiocytoma was the most common histology encountered (41%). Synovial sarcoma was the second most common histology encountered (14.38%). Recurrence was observed in 14 (10.1%) patients. The overall survival was 64.7% in our study. Conclusions The surgical margin achieved during the surgery is the most detrimental factor in local tumor control, and the overall survival of the patient after resection mainly depends on the stage of the tumor.

摘要

背景 软组织肉瘤(STSs)是一组罕见的异质性肿瘤。如果需要,通过肿瘤切除联合合适的辅助治疗可取得良好的功能结果。本研究旨在探讨肢体软组织肉瘤广泛切除的疗效。方法 在这项回顾性研究中,纳入了139例经影像学和/或组织病理学检查/活检确诊为肢体软组织肉瘤的患者。所有患者,无论有无转移均被纳入。结果 本研究中患者的平均年龄为43.5±18.89岁。总体而言,平均肿瘤大小为11.81±6.218厘米。恶性纤维组织细胞瘤是最常见的组织学类型(41%)。滑膜肉瘤是第二常见的组织学类型(14.38%)。14例(10.1%)患者出现复发。本研究中的总生存率为64.7%。结论 手术中获得的手术切缘是局部肿瘤控制中最关键的因素,切除术后患者的总生存主要取决于肿瘤分期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88b7/9413370/016bbf8d9c31/cureus-0014-00000027329-i01.jpg

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