互隔交链孢酚A-E，由内生真菌sp. YUD20002产生的五种环氧八氢萘聚酮化合物。
Altereporenes A-E, five epoxy octa-hydronaphthalene polyketides produced by an endophytic fungus sp. YUD20002.
作者信息
Xia Dan-Dan, Duan Hao-Jie, Xie Fei, Xie Tian-Peng, Zhang Yan, Sun Yue, Lu Jian-Mei, Gao Yu-Hong, Zhou Hao, Ding Zhong-Tao
机构信息
Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University Kunming 650091 China
The First People's Hospital of Yunnan Province Kunming 650034 China.
出版信息
RSC Adv. 2022 Aug 10;12(34):22295-22301. doi: 10.1039/d2ra03917f. eCollection 2022 Aug 4.
Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes A-E (1-5) were isolated from rice culture of the endophytic fungus sp. YUD20002 derived from the tubers of . Their structures were determined on the basis of comprehensive spectroscopic analyses, while the absolute configurations were elucidated by the comparison of experimental and calculated specific rotations. Meanwhile, the antimicrobial, cytotoxic, anti-inflammatory and acetylcholinesterase inhibitory activities of compounds 1-5 were also investigated.
从来源于[植物名称]块茎的内生真菌[真菌名称]sp. YUD20002的水稻培养物中分离出了5种以前未描述过的环氧八氢萘聚酮化合物，即变戊二烯素A-E（1-5）。它们的结构通过综合光谱分析确定，而绝对构型则通过实验比旋度和计算比旋度的比较来阐明。同时，还研究了化合物1-5的抗菌、细胞毒性、抗炎和乙酰胆碱酯酶抑制活性。
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