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肺芽生菌病表现为咽后脓肿导致的急性气道梗阻，并在泊沙康唑治疗期间并发严重低钾血症：一例报告及文献复习

Blastomycosis Presenting With Acute Airway Obstruction From a Retropharyngeal Abscess and Complicated by Severe Hypokalemia During Posaconazole Therapy: A Case Report and Review of Literature.

作者信息

Hanna John J, Guastadisegni Jessica M, Kouma Marcus A, Knez Emily B, Arasaratnam Reuben J, Storey Donald F

机构信息

Department of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Medicine Service, Infectious Disease Section, Veterans Affairs North Texas Health Care System, Dallas, Texas, USA.

出版信息

Open Forum Infect Dis. 2022 Aug 11;9(8):ofac414. doi: 10.1093/ofid/ofac414. eCollection 2022 Aug.

DOI:10.1093/ofid/ofac414
PMID:36043181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9416057/
Abstract

We report a case of cervical blastomycosis with associated paravertebral involvement and severe spinal canal stenosis in a 48-year-old patient presenting with acute airway obstruction from a retropharyngeal abscess. Our case was also complicated by severe hypokalemia that developed during the blastomycosis treatment course with posaconazole and which improved after discontinuation and replacement therapy. After 12 months of blastomycosis-targeted therapy, our patient had complete resolution of clinical, laboratory, and radiological findings of blastomycosis.

摘要

我们报告一例48岁患者的颈部芽生菌病，伴有椎旁受累及严重的椎管狭窄，该患者因咽后脓肿导致急性气道梗阻。我们的病例还并发了严重低钾血症，在使用泊沙康唑治疗芽生菌病过程中出现，停药及替代治疗后有所改善。经过12个月的芽生菌病靶向治疗，我们的患者芽生菌病的临床、实验室及影像学表现完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/1995eaa93cbf/ofac414f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/285c429b8d2e/ofac414f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/650ad4ab94cf/ofac414f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/aa7d5969c60f/ofac414f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/ab67b22f9df9/ofac414f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/1995eaa93cbf/ofac414f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/285c429b8d2e/ofac414f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/650ad4ab94cf/ofac414f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/aa7d5969c60f/ofac414f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/ab67b22f9df9/ofac414f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3a6/9416057/1995eaa93cbf/ofac414f5.jpg

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Management of posaconazole-induced pseudohyperaldosteronism.泊沙康唑诱导的假性醛固酮增多症的管理。
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Atypical Retropharyngeal Abscess of Tuberculosis: Diagnostic Reasoning, Management, and Treatment.非典型结核性咽后脓肿：诊断思路、管理与治疗
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Diagnosis, and Treatment of Cervical Epidural Abscess and/or Cervical Vertebral Osteomyelitis with or without Retropharyngeal Abscess; A Review.伴有或不伴有咽后脓肿的颈椎硬膜外脓肿和/或颈椎骨髓炎的诊断与治疗；综述
Surg Neurol Int. 2020 Jun 20;11:160. doi: 10.25259/SNI_294_2020. eCollection 2020.
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Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.泊沙康唑和伊曲康唑诱导的假性醛固酮增多症的分子机制，以及其他系统使用的唑类抗真菌药物的评估。
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