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妊娠期手足口病的罕见表现

A Rare Presentation of Hand, Foot, and Mouth Disease During Pregnancy.

作者信息

Alam Mohammad R, Rokaya Nabin, Mahat Smritee, Upadhyaya Ashutosh, Rokaya Pranjal

机构信息

Internal Medicine, Arghakhanchi District Hospital, Arghakhanchi, NPL.

General Practice, Humla District Hospital, Simikot, NPL.

出版信息

Cureus. 2022 Aug 25;14(8):e28401. doi: 10.7759/cureus.28401. eCollection 2022 Aug.

DOI:10.7759/cureus.28401
PMID:36043199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9411823/
Abstract

This case report is about an 18-year-old primigravida diagnosed with hand, foot, and mouth disease (HFMD) at 34 weeks of gestation. She had classic rashes on her hands and mouth but was otherwise healthy. The baby was delivered at 39 weeks via spontaneous normal vaginal delivery and was well after delivery. We provide a brief literature review on HFMD in pregnancy and a brief discussion on complications caused by the causative organisms.

摘要

本病例报告讲述的是一名18岁初产妇，在妊娠34周时被诊断为手足口病（HFMD）。她手上和嘴上有典型皮疹，但其他方面健康。婴儿于39周时经自然正常阴道分娩出生，出生后情况良好。我们对手足口病在孕期的情况进行了简要文献综述，并对手足口病致病微生物引起的并发症进行了简要讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55e/9411823/8093e5b7bc77/cureus-0014-00000028401-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55e/9411823/a3a6f01e763d/cureus-0014-00000028401-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55e/9411823/8093e5b7bc77/cureus-0014-00000028401-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55e/9411823/a3a6f01e763d/cureus-0014-00000028401-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55e/9411823/8093e5b7bc77/cureus-0014-00000028401-i02.jpg

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本文引用的文献

1
Enterovirus-Associated Hand-Foot and Mouth Disease and Neurological Complications in Japan and the Rest of the World.肠道病毒相关性手足口病和神经系统并发症：日本及世界其他地区的情况。
Int J Mol Sci. 2019 Oct 20;20(20):5201. doi: 10.3390/ijms20205201.
2
Adult Hand, Foot, and Mouth Disease.成人手足口病
Ear Nose Throat J. 2020 Nov;99(9):NP105-NP106. doi: 10.1177/0145561319856569. Epub 2019 Jun 17.
3
Adverse effects of maternal enterovirus infection on the pregnancy outcome: a prospective and retrospective pilot study.
母亲肠道病毒感染对妊娠结局的不良影响：一项前瞻性和回顾性的初步研究。
Virol J. 2018 Apr 16;15(1):70. doi: 10.1186/s12985-018-0978-7.
4
[Enterovirus infection during pregnancy: Underestimated cause of fetal and neonatal complications?].[孕期肠道病毒感染：胎儿及新生儿并发症被低估的病因？]
Gynecol Obstet Fertil Senol. 2017 Apr;45(4):231-237. doi: 10.1016/j.gofs.2017.02.004. Epub 2017 Mar 31.
5
Coxsackievirus B4 vertical transmission in a murine model.柯萨奇病毒B4在小鼠模型中的垂直传播
Virol J. 2017 Jan 31;14(1):16. doi: 10.1186/s12985-017-0689-5.
6
The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis.亚洲手足口病的流行病学：系统评价与分析
Pediatr Infect Dis J. 2016 Oct;35(10):e285-300. doi: 10.1097/INF.0000000000001242.
7
Coxsackie Virus A16 Infection of Placenta with Massive Perivillous Fibrin Deposition Leading to Intrauterine Fetal Demise at 36 Weeks Gestation.柯萨奇病毒A16感染胎盘并伴有大量绒毛周围纤维蛋白沉积，导致孕36周时胎儿宫内死亡。
Pediatr Dev Pathol. 2015 Jul-Aug;18(4):331-4. doi: 10.2350/15-01-1603-CR.1. Epub 2015 Mar 31.
8
Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies.肠道病毒感染与 1 型糖尿病：观察性分子研究的系统评价和荟萃分析。
BMJ. 2011 Feb 3;342:d35. doi: 10.1136/bmj.d35.
9
Probable intrafamilial transmission of coxsackievirus b3 with vertical transmission, severe early-onset neonatal hepatitis, and prolonged viral RNA shedding.柯萨奇病毒B3可能通过垂直传播在家族内传播，导致严重的早发型新生儿肝炎，并伴有病毒RNA长期脱落。
Pediatrics. 2006 Sep;118(3):e929-33. doi: 10.1542/peds.2006-0554. Epub 2006 Aug 14.
10
Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses.柯萨奇病毒、埃可病毒、麻疹病毒、腮腺炎病毒、肝炎病毒、脊髓灰质炎病毒及脑炎病毒感染后的妊娠结局
Reprod Toxicol. 2006 May;21(4):446-57. doi: 10.1016/j.reprotox.2005.12.007. Epub 2006 Feb 9.