College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Chem Commun (Camb). 2022 Sep 20;58(75):10524-10527. doi: 10.1039/d2cc03753j.
We demonstrate the construction of an aggregation-induced electrochemiluminescent (AIECL) sensor for glutathione (GSH) assay by integrating an aminal-linked covalent organic framework (A-COF) with manganese dioxide (MnO) nanosheets. The AIECL of the A-COF is quenched by the MnO nanosheets electrochemiluminescent resonance energy transfer (ERET) from the excited A-COF to MnO. The presence of GSH can reduce the MnO nanosheets into Mn, restoring the AIECL emission of the A-COF. This AIECL sensor has the characteristics of fast response, high sensitivity, and good selectivity toward GSH, and it can accurately measure GSH in human serum.
我们通过将胺基连接的共价有机框架（A-COF）与二氧化锰（MnO）纳米片集成，展示了一种用于谷胱甘肽（GSH）分析的聚集诱导电化学发光（AIECL）传感器的构建。MnO 纳米片通过电化学发光共振能量转移（ERET）从激发态的 A-COF 猝灭 A-COF 的 AIECL。GSH 的存在可以将 MnO 纳米片还原为 Mn，从而恢复 A-COF 的 AIECL 发射。该 AIECL 传感器对 GSH 具有快速响应、高灵敏度和良好选择性的特点，可以准确测量人血清中的 GSH。
