Department of Pharmaceutical Science, Susruta School of Medical and Paramedical Sciences, Assam University, Silchar, India.
Mini Rev Med Chem. 2023;23(13):1360-1375. doi: 10.2174/1389557522666220829085805.
Cellulose Nanocrystals (CNCs) have been touted to be among the materials of the 21 century. It is an emerging biocompatible and biodegradable nanomaterial with unique physicochemical properties adaptable to various surface modifications. The characteristics and properties of CNCs are now understood to depend upon the source of the cellulose and the conditions of its isolation. Over the past decade, CNCs with various morphologies, including rod, ribbon, needle shapes, spherical, square, block and rectangular shapes with unique surface properties, have been synthesized. Studies have shown that surface and morphological properties of CNCs have substantial control over the rheology, cytotoxicity and cellular uptake, which ultimately influence its purposive biomedical applications. The objective of the current survey is to analyze the advances made in the shape-controlled synthesis and fabrication of CNCs morphology and review the influence such morphological variations have on its functionality in biomedical fields.
纤维素纳米晶体（CNCs）被誉为 21 世纪的材料之一。它是一种新兴的生物相容性和可生物降解的纳米材料，具有独特的物理化学性质，可适应各种表面修饰。CNCs 的特性和性能现在被认为取决于纤维素的来源及其分离条件。在过去的十年中，已经合成了具有各种形态的 CNCs，包括棒状、带状、针状、球形、方形、块状和矩形，具有独特的表面性质。研究表明，CNCs 的表面和形态特性对其流变学、细胞毒性和细胞摄取有很大的控制作用，这最终影响其在有目的的生物医学应用中的作用。本综述的目的是分析在 CNCs 形态的形状控制合成和制造方面取得的进展，并综述这种形态变化对其在生物医学领域的功能的影响。
