Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head & Neck Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Facial Plast Surg Aesthet Med. 2023 Jan-Feb;25(1):61-67. doi: 10.1089/fpsam.2021.0348. Epub 2022 Aug 30.
Granulomatosis with polyangiitis (GPA) leads to progressive destruction of the nasal tissues resulting varying degrees of saddle deformity and nasal obstruction. Reconstructive techniques are numerous, but there are no large series reporting their results. This study sought to measure complications and outcomes after rhinoplasty for GPA. We conducted a retrospective review of 42 patients with GPA who underwent nasal reconstruction of saddle nose deformity between 2005 and 2019 using primarily costal cartilage and soft tissue grafts. Thirty-six patients met the criteria for inclusion. All were followed for a minimum of 12 months. Six patients required revision surgery due to infection or GPA flare ups. Five patients had complications. All patients were given a questionnaire at 12 months to rate their degree of satisfaction with their appearance and breathing. The findings of this study suggest that the use of strong cartilage grafts and the timing of surgery result in improvement in breathing and appearance after rhinoplasty in patients with GPA. Clinical Trial Registration number: REB # 21-125.
肉芽肿性多血管炎（GPA）可导致鼻组织进行性破坏，从而导致不同程度的鞍鼻畸形和鼻阻塞。重建技术多种多样，但尚无大型系列报告其结果。本研究旨在评估 GPA 患者接受鼻整形术的并发症和结果。我们对 2005 年至 2019 年间使用主要肋软骨和软组织移植物进行鞍鼻畸形鼻重建的 42 例 GPA 患者进行了回顾性研究。36 例患者符合纳入标准。所有患者均至少随访 12 个月。6 例患者因感染或 GPA 发作需要进行翻修手术。5 例患者出现并发症。所有患者在 12 个月时都接受了问卷调查，以评估他们对自己外观和呼吸的满意度。这项研究的结果表明，使用强有力的软骨移植物和手术时机可改善 GPA 患者鼻整形术后的呼吸和外观。临床试验注册号：REB#21-125。
