NDUFS4促进胃癌肿瘤进展并预测其预后。
NDUFS4 promotes tumor progression and predicts prognosis in gastric cancer.
作者信息
Cheng Tong, Jiang Boxuan, Xu Manyu, Yuan Chengzhe, Tai Mingliang, Wu Han, Lu Bing, Sun Pingping, Jiang Xiaohui, Zhang Xiaojing
机构信息
Department of Clinical Biobank, Affiliated Hospital of Nantong University & Medical school of Nantong University, Jiangsu 226001, China.
Department of General Surgery, Nantong Tumor Hospital, Nantong, Jiangsu 226361, China.
出版信息
Carcinogenesis. 2022 Nov 23;43(10):980-987. doi: 10.1093/carcin/bgac074.
Gastric cancer ranked third worldwide in terms of mortality. The immediate priority is to search for new prognosticative or therapeutic targets. This research aims to examine the function of the NADH:ubiquinone oxidoreductase subunit S4 (NDUFS4) in the malignant phenotype of gastric carcinoma. We analyzed the correlation between NDUFS4 expression and gastric cancer via bioinformatics analysis and cancer tissue microarray via immunohistochemistry. Also, we detected the phenotype change in gastric cancer cells after NDUFS4 was downregulated. NDUFS4's high expression in gastric cancer tissues showed an association with terminal TNM stage and unfavorable survival. Furthermore, downregulation of NDUFS4 decreased gastric cancer cell proliferation, migration and invasion. Nude mouse models revealed that NDUFS4 promotes tumor growth. This investigation highlights the prognostic role of NDUFS4 in gastric cancer. Our results also creatively ascertained NDUFS4 as a candidate for gastric cancer therapeutic targets.
胃癌的死亡率在全球排名第三。当务之急是寻找新的预后或治疗靶点。本研究旨在探讨NADH：泛醌氧化还原酶亚基S4（NDUFS4）在胃癌恶性表型中的作用。我们通过生物信息学分析以及免疫组化法检测癌组织芯片，分析了NDUFS4表达与胃癌之间的相关性。此外，我们还检测了NDUFS4表达下调后胃癌细胞的表型变化。NDUFS4在胃癌组织中的高表达与终末期TNM分期及不良预后相关。此外，NDUFS4表达下调会降低胃癌细胞的增殖、迁移和侵袭能力。裸鼠模型显示，NDUFS4可促进肿瘤生长。本研究突出了NDUFS4在胃癌中的预后作用。我们的研究结果还创新性地确定了NDUFS4作为胃癌治疗靶点的候选地位。
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