Trzenschik K, Marx I
Zentralbl Allg Pathol. 1987;133(2):147-53.
The physiological pH-value of the synovial fluid (pH 7.2-7.4) is important for the integrity of normal articular cartilage. After the intraarticular injection of acid (pH 4.0) or alkaline (pH 10.0) isoosmolale buffer solutions into the knee joints of young rabbits ultrastructural changes are seen by the aid of transmission electron microscopy. The number of cell organelles in the chondrocytes (rough endoplasmic reticulum, Golgi-complex, mitochondria) is diminished and the number of intracytoplasmic filaments is increased. The intercellular matrix shows a looseness of the collagen fibre mesh work, swollen and split collagen fibres, the appearance of numerous coarse rounded structures with an electron dense envelop, and a loss of matrix granules. These results are interpreted as regressive changes, and they are discussed in the context of an activation of proteinases.
滑液的生理pH值（pH 7.2 - 7.4）对正常关节软骨的完整性很重要。向幼兔膝关节内注射酸性（pH 4.0）或碱性（pH 10.0）等渗缓冲溶液后，借助透射电子显微镜可观察到超微结构变化。软骨细胞中的细胞器（粗面内质网、高尔基体、线粒体）数量减少，细胞质内细丝数量增加。细胞间基质显示胶原纤维网疏松、胶原纤维肿胀和分裂、出现许多带有电子致密包膜的粗大圆形结构以及基质颗粒丢失。这些结果被解释为退行性变化，并在蛋白酶激活的背景下进行了讨论。
