Kim In Jae, Kim Woohyeun, Go Tae Hwa, Kang Dae Ryong, Kim Jang-Young, Kim Eung Ju
Department of Cardiology, Namwon Medical Center, Namwon, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, 04763, Seoul, Republic of Korea.
Clin Hypertens. 2022 Sep 1;28(1):24. doi: 10.1186/s40885-022-00206-5.
A previous study based on urban areas suggested the age- and sex-dependent association of uric acid (UA) and incident hypertension. We aimed to investigate whether this association is valid even in rural areas with different lifestyle.
Data from the cardiovascular disease association study, a prospective cohort study based on rural residents, was analyzed. A total of 4,592 subjects (mean age, 60.1 ± 9.5 years; men, 37.7%) without hypertension were included. We first investigated whether UA was a risk factor for incident hypertension using Cox regression, and then compared the relative risk by stratification according to age and sex.
During the follow-up period (mean, 2.0 years), 579 subjects (12.6%) were newly diagnosed with hypertension. The risk factors for incident hypertension were age (Hazard ratios [HR] for ≥ 65, 1.26), systolic blood pressure (HR per 1 mmHg increase, 1.07), and serum UA concentration (HR per 1 mmHg increase, 1.10). The risk of UA-related incident hypertension was higher in the non-elderly than in the elderly for both men and women (HR, 1.74 for non-elderly men; 1.88 for non-elderly women; 1.66 for elderly men; 1.10 for elderly women). Even after adjusting for multiple confounders, the risk of UA-related incident hypertension was significantly higher in non-elderly women (HR, 1.59; P < 0.05).
Age- and sex-dependent association of UA with incident hypertension suggested in cohort study based on urban areas was consistently found in rural areas as well. In particular, non-elderly women were at a higher risk for UA-related incident hypertension.
先前一项基于城市地区的研究表明尿酸（UA）与高血压发病存在年龄和性别依赖性关联。我们旨在调查这种关联在生活方式不同的农村地区是否也成立。
分析了心血管疾病关联研究的数据，该研究是一项基于农村居民的前瞻性队列研究。共纳入4592名无高血压的受试者（平均年龄60.1±9.5岁；男性占37.7%）。我们首先使用Cox回归研究尿酸是否为高血压发病的危险因素，然后根据年龄和性别分层比较相对风险。
在随访期间（平均2.0年），579名受试者（12.6%）新诊断为高血压。高血压发病的危险因素包括年龄（≥65岁的风险比[HR]为1.26）、收缩压（每升高1 mmHg的HR为1.07）和血清尿酸浓度（每升高1 mmHg的HR为1.10）。无论男性还是女性，非老年人中尿酸相关高血压发病风险均高于老年人（非老年男性HR为1.74；非老年女性HR为1.88；老年男性HR为1.66；老年女性HR为1.10）。即使在调整多个混杂因素后，非老年女性尿酸相关高血压发病风险仍显著更高（HR为1.59；P<0.05）。
基于城市地区的队列研究中提示的尿酸与高血压发病的年龄和性别依赖性关联在农村地区也得到了一致发现。特别是，非老年女性患尿酸相关高血压发病的风险更高。
