Spinal Cord Injury Rehabilitation Clinic, Patras University Hospital, Athens, Greece.
Rheumatology Department, Aghios Pavlos General Hospital, Thessaloniki, Greece.
Folia Med (Plovdiv). 2022 Aug 31;64(4):596-601. doi: 10.3897/folmed.64.e63530.
Diseases such as diabetes mellitus may be associated with adverse changes in body composition. Sarcopenia is characterized by a progressive and generalized loss of skeletal muscle mass and functionality.
To investigate the relationship between type 2 diabetes mellitus (T2DM) and sarcopenia.
In a retrospective, non-randomized study, 35 T2DM patients, aged 20-80 years, were assessed for sarcopenia prevalence compared to controls (n=16). Appendicular skeletal mass (ASM) (kg) was measured, and sarcopenia was defined as SMI <7.0 and <5.7 kg/m2, in males and females, respectively, using the European Working Group on Sarcopenia in Elderly (EWGOSP) definition. Low physical performance was defined as a walking speed of <0.8 m/s.
Incidence of sarcopenia was significantly higher in T2DM patients vs. controls (27% vs. 20%, p=0.01) and elderly vs. young participants (40% vs. 12%, p<0.001), respectively. Walking velocity was significantly lower in T2DM patients compared to male and female controls (1.08±0.22 vs. 1.23±0.18 and 1.07±0.26 vs. 1.26±0.16, respectively, p<0.001,).
A moderate prevalence of sarcopenia in patients with type 2 diabetes mellitus was observed, which appeared to increase significantly in older men. Finally, incidence of T2DM displayed decreased physical performance in both genders.
糖尿病等疾病可能与身体成分的不利变化有关。肌少症的特征是骨骼肌质量和功能进行性和全身性丧失。
研究 2 型糖尿病（T2DM）与肌少症的关系。
在一项回顾性、非随机研究中，评估了 35 名年龄在 20-80 岁的 T2DM 患者与对照组（n=16）的肌少症患病率。使用欧洲老年人肌少症工作组（EWGOSP）定义，分别测量四肢骨骼肌质量（ASM）（kg），男性和女性的肌少症定义为 SMI<7.0 和<5.7 kg/m2。低身体表现定义为行走速度<0.8 m/s。
T2DM 患者的肌少症发生率明显高于对照组（27%比 20%，p=0.01），老年患者比年轻患者（40%比 12%，p<0.001）。T2DM 患者的行走速度明显低于男性和女性对照组（1.08±0.22 比 1.23±0.18 和 1.07±0.26 比 1.26±0.16，均 p<0.001）。
在 2 型糖尿病患者中观察到肌少症的中度患病率，在老年男性中似乎明显增加。最后，T2DM 的发生率在两性中均表现出身体机能下降。
