Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jiangsu University Library, Zhenjiang, China.
Sci Rep. 2016 Dec 13;6:38937. doi: 10.1038/srep38937.
Sarcopenia is a condition characterized by progressive and generalized loss of skeletal muscle mass and function. In this study, we used a cross-sectional study with 1090 community-dwelling Chinese citizens aged 60 years and older to evaluate the association of type 2 diabetes mellitus (T2DM) with the risk of sarcopenia and pre-sarcopenia. Sarcopenia was defined using the Asian Working Group for Sarcopenia (AWGS) criteria that include both muscle mass and muscle function/physical activity. Pre-sarcopenia was defined as having low skeletal muscle index but with normal muscle/physical activity. The prevalence of sarcopenia and pre-sarcopenia was significantly higher in T2DM patients than in healthy controls (14.8% vs. 11.2%, p = 0.035 for sarcopenia, and 14.4% vs. 8.4%, p = 0.002 for pre-sarcopenia). In multivariate logistic regression analyses adjusting by age, gender, anti-diabetic medication, energy intake, protein intake, physical activity, and visceral fat area, we found that Chinese elderly with T2DM exhibited significantly increased risks of sarcopenia (OR = 1.37, 95% CI = 1.02-2.03) and pre-sarcopenia (OR = 1.73, 95% CI = 1.10-2.83) compared to non-diabetic individuals. This is the first study to evaluate the association of T2DM with the risks of sarcopenia and pre-sarcopenia in China. Among a group of community-dwelling Chinese elderly, T2DM was significantly associated with increased risks of sarcopenia and pre-sarcopenia.
肌少症是一种以骨骼肌质量和功能进行性和广泛性丧失为特征的疾病。在这项研究中，我们使用了一项横断面研究，纳入了 1090 名年龄在 60 岁及以上的社区居民，评估 2 型糖尿病（T2DM）与肌少症和肌少前症风险的相关性。肌少症采用亚洲肌少症工作组（AWGS）标准定义，包括肌肉质量和肌肉功能/体力活动。肌少前症定义为骨骼肌指数低但肌肉/体力活动正常。与健康对照组相比，T2DM 患者的肌少症和肌少前症患病率显著更高（肌少症 14.8% vs. 11.2%，p=0.035，肌少前症 14.4% vs. 8.4%，p=0.002）。在调整年龄、性别、降糖药物、能量摄入、蛋白质摄入、体力活动和内脏脂肪面积后进行多变量逻辑回归分析，我们发现，与非糖尿病个体相比，中国老年 T2DM 患者肌少症（OR=1.37，95%CI=1.02-2.03）和肌少前症（OR=1.73，95%CI=1.10-2.83）的风险显著增加。这是第一项在中国评估 T2DM 与肌少症和肌少前症风险相关性的研究。在一组社区居住的中国老年人中，T2DM 与肌少症和肌少前症风险增加显著相关。
