Iliadi-Tulbure Corina, Cemortan Maria, Bubulici Cristina, Botnari-Gutu Mihaela, Cernetchi Olga
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova.
Folia Med (Plovdiv). 2022 Aug 31;64(4):688-692. doi: 10.3897/folmed.64.e65939.
Intrahepatic cholestasis of pregnancy is pregnancy-specific liver disorder, characterized by pruritus as the main clinical symptom, and fasting liver function tests. The term thrombophilia is used to describe a group of conditions characterized by blood coagulation disorder with increased risk of blood clot formation, which may be congenital or acquired. In general, population the incidence of thrombophilia and intrahepatic cholestasis of pregnancy varies widely, depending on the type of disorder (in case of congenital thrombophilia) and geographical distribution (in case of intrahepatic cholestasis of pregnancy). A high incidence of pregnancy complications makes both congenital thrombophilia and intrahepatic cholestasis of pregnancy very important in clinical practice. At the same time, association between these two disorders is extremely complicated in management, due to perinatal risks. The key-point for the management is cooperation among obstetricians, hematologists, and hepatologists, being crucial for better outcomes.
妊娠期肝内胆汁淤积症是一种妊娠期特有的肝脏疾病，其主要临床症状为瘙痒，并伴有空腹肝功能检查异常。术语“易栓症”用于描述一组以凝血功能障碍、血栓形成风险增加为特征的病症，这些病症可能是先天性的，也可能是后天获得的。一般来说，在人群中，易栓症和妊娠期肝内胆汁淤积症的发病率差异很大，这取决于疾病类型（对于先天性易栓症）和地理分布（对于妊娠期肝内胆汁淤积症）。妊娠并发症的高发生率使得先天性易栓症和妊娠期肝内胆汁淤积症在临床实践中都非常重要。同时，由于围产期风险，这两种疾病之间的关联在管理上极为复杂。管理的关键在于产科医生、血液科医生和肝病科医生之间的合作，这对于获得更好的结果至关重要。
