Women's Health Academic Centre, King's College London, and Department of Obstetrics and Gynaecology, University College London, London, United Kingdom.
Obstet Gynecol. 2014 Jul;124(1):120-133. doi: 10.1097/AOG.0000000000000346.
Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including spontaneous preterm delivery, meconium staining of the amniotic fluid, and stillbirth. It is commonly treated with ursodeoxycholic acid. There is accumulating evidence to suggest that intrahepatic cholestasis of pregnancy has a lasting influence on both maternal and fetal health. We review the etiology, diagnosis, and management of this intriguing condition.
妊娠肝内胆汁淤积症是最常见的妊娠特发性肝脏疾病，通常在妊娠晚期出现。其临床特征为孕妇无皮疹但伴有瘙痒，以及肝功能检查异常，包括血清胆汁酸升高。妊娠肝内胆汁淤积症与不良围产儿结局风险增加相关，包括自发性早产、羊水胎粪污染和死胎。其通常采用熊去氧胆酸治疗。越来越多的证据表明，妊娠肝内胆汁淤积症对母婴健康均有持久影响。我们对这种特殊疾病的病因、诊断和处理进行了综述。
