Department of Molecular and Comparative Pathobiology, Research Animal Resources, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Med Primatol. 2022 Dec;51(6):374-380. doi: 10.1111/jmp.12608. Epub 2022 Aug 31.
Shigella spp. are common enteric pathogens in captive non-human primates. Treatment of symptomatic infections involves supportive care and antibiotic therapy, typically with an empirical choice of antibiotic.
Twenty-four clinically ill, Shigella PCR-positive animals were randomly assigned to one of four treatment groups: single-dose ceftiofur crystalline free acid (CCFA), single-dose azithromycin gavage, a 5-day tapering azithromycin dose, or 7-day course of enrofloxacin. We hypothesized that all antimicrobial therapies would have similar efficacy.
Animals in all groups cleared Shigella, based on fecal PCR, and had resolution of clinical signs 2 weeks after treatment. Eight out of nine clinically ill and PCR-positive animals tested negative by fecal culture.
Single-dose CCFA, single-dose azithromycin, and a 5-day tapering course of azithromycin all performed as well as a 7-day course of enrofloxacin in eliminating Shigella infection. Fecal PCR may be a better diagnostic than culture for Shigella.
志贺氏菌属是圈养非人类灵长类动物中常见的肠道病原体。对有症状的感染的治疗包括支持性护理和抗生素治疗，通常采用经验性选择抗生素。
24 只患有志贺氏菌属 PCR 阳性的临床感染的动物被随机分配到四个治疗组之一：单次剂量头孢噻呋结晶游离酸（CCFA）、单次剂量阿奇霉素灌胃、5 天递减剂量阿奇霉素或 7 天疗程的恩诺沙星。我们假设所有的抗菌治疗都具有相似的疗效。
所有组的动物在治疗后 2 周内，基于粪便 PCR 清除了志贺氏菌，并解决了临床症状。9 只临床感染和 PCR 阳性的动物中有 8 只粪便培养呈阴性。
单次剂量 CCFA、单次剂量阿奇霉素和 5 天递减剂量阿奇霉素的疗效与 7 天疗程的恩诺沙星一样，均能消除志贺氏菌感染。粪便 PCR 可能比培养更适合用于诊断志贺氏菌。
