Peng Guangxin, Tang Xiaoling, Gui Yang, Yang Jing, Ye Lifang, Wu Liuyang, Ding Ya Hui, Wang Lihong
Zhejiang University of Technology, Hangzhou, China.
Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Front Physiol. 2022 Aug 15;13:951980. doi: 10.3389/fphys.2022.951980. eCollection 2022.
The transient receptor potential vanilloid subtype 1 (TRPV1), belonging to the TRPV channel family, is a non-selective, calcium-dependent, cation channel implicated in several pathophysiological processes. Collagen, an extracellular matrix component, can accumulate under pathological conditions and may lead to the destruction of tissue structure, organ dysfunction, and organ failure. Increasing evidence indicates that TRPV1 plays a role in the development and occurrence of fibrotic diseases, including myocardial, renal, pancreatic, and corneal fibrosis. However, the mechanism by which TRPV1 regulates fibrosis remains unclear. This review highlights the comprehensive role played by TRPV1 in regulating pro-fibrotic processes, the potential of TRPV1 as a therapeutic target in fibrotic diseases, as well as the different signaling pathways associated with TRPV1 and fibrosis.
瞬时受体电位香草酸亚型1（TRPV1）属于TRPV通道家族，是一种非选择性、钙依赖性阳离子通道，参与多种病理生理过程。胶原蛋白是细胞外基质的一种成分，在病理条件下会积聚，并可能导致组织结构破坏、器官功能障碍和器官衰竭。越来越多的证据表明，TRPV1在纤维化疾病（包括心肌纤维化、肾纤维化、胰腺纤维化和角膜纤维化）的发生发展中起作用。然而，TRPV1调节纤维化的机制仍不清楚。本综述重点介绍了TRPV1在调节促纤维化过程中的综合作用、TRPV1作为纤维化疾病治疗靶点的潜力，以及与TRPV1和纤维化相关的不同信号通路。
