Jiang Zhipeng, Luo Wen, Long Zongmin, Chen Jie
Third Affiliated Hospital of Zunyi Medical University (First People's Hospital of Zunyi), Zunyi, China.
Kweichow Moutai Hospital, Zunyi, China.
Front Pharmacol. 2024 Sep 19;15:1459683. doi: 10.3389/fphar.2024.1459683. eCollection 2024.
Chronic prostatitis is a prevalent male urinary system disorder characterized by pelvic discomfort or pain, bladder dysfunction, sexual dysfunction, and infertility. Pain and lower urinary tract symptoms (LUTS) are the most common symptoms, significantly impacting patients' quality of life and driving them to seek medical attention. Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective calcium ion-dependent cation channel in the TRPV channel family that is widely distributed in neural tissue and plays a role in signal transmission. In this review, we provide a comprehensive overview of the current understanding of the role of TRPV1 in chronic prostatitis. The discussion focuses on the connection between TRPV1 and prostatitis pain and LUTS, and highlights the potential for targeting this channel in the development of novel treatment strategies.
慢性前列腺炎是一种常见的男性泌尿系统疾病，其特征为盆腔不适或疼痛、膀胱功能障碍、性功能障碍及不育。疼痛和下尿路症状（LUTS）是最常见的症状，严重影响患者的生活质量并促使他们寻求医疗帮助。瞬时受体电位香草酸亚型1（TRPV1）是TRPV通道家族中的一种非选择性钙离子依赖性阳离子通道，广泛分布于神经组织中并在信号传递中发挥作用。在本综述中，我们全面概述了目前对TRPV1在慢性前列腺炎中作用的认识。讨论聚焦于TRPV1与前列腺炎疼痛及LUTS之间的联系，并强调了在新型治疗策略开发中靶向该通道的潜力。
