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欧陆明(巴瑞替尼)口服片剂:深入了解美国食品药品监督管理局批准的斑秃系统性治疗药物

Olumniant (Baricitinib) oral tablets: An insight into FDA-approved systemic treatment for Alopecia Areata.

作者信息

Ali Eman, Owais Rabia, Sheikh Ayesha, Shaikh Asim

机构信息

Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.

出版信息

Ann Med Surg (Lond). 2022 Jul 13;80:104157. doi: 10.1016/j.amsu.2022.104157. eCollection 2022 Aug.

DOI:10.1016/j.amsu.2022.104157
PMID:36045780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9422172/
Abstract

Olumniant (Barcitinib) has gained swift approval by the Food and Drug Administration (FDA) as a promising medication for the treatment of adults with severe Alopecia Areata. This drug has proven to be effective for various conditions including Covid-19 and Rheumatoid Arthritis as well as being found to be less costly and minimally invasive, with no need for post-operative management. However, its use has some considerable potential implications before its prescription can be made commonplace. Therefore, more trials need to be conducted to establish a more rigid safety profile.

摘要

欧鲁明(巴瑞替尼)已迅速获得美国食品药品监督管理局(FDA)的批准,成为一种有前景的药物,用于治疗重度斑秃的成年人。这种药物已被证明对包括新冠病毒病和类风湿性关节炎在内的各种病症有效,而且成本较低、侵入性极小,无需术后管理。然而,在其处方变得普遍之前,其使用存在一些相当大的潜在影响。因此,需要进行更多试验以建立更严格的安全档案。

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Ann Med Surg (Lond). 2022 Jul 13;80:104157. doi: 10.1016/j.amsu.2022.104157. eCollection 2022 Aug.
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本文引用的文献

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A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata.JAK抑制剂治疗斑秃的综合文献综述
Clin Cosmet Investig Dermatol. 2021 Jun 25;14:691-714. doi: 10.2147/CCID.S309215. eCollection 2021.
2
Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study.口服Janus激酶抑制剂巴瑞替尼治疗成人生斑秃的疗效和安全性:一项随机对照研究的2期结果
J Am Acad Dermatol. 2021 Oct;85(4):847-853. doi: 10.1016/j.jaad.2021.05.050. Epub 2021 Jun 16.
3
Alopecia Areata: New Treatment Options Including Janus Kinase Inhibitors.斑秃:包括 Janus 激酶抑制剂在内的新治疗选择
Dermatol Clin. 2021 Jul;39(3):407-415. doi: 10.1016/j.det.2021.03.005. Epub 2021 May 15.
4
Baricitinib: From Rheumatoid Arthritis to COVID-19.巴瑞替尼:从类风湿关节炎到 COVID-19。
J Clin Pharmacol. 2021 Oct;61(10):1274-1285. doi: 10.1002/jcph.1874. Epub 2021 Jun 12.
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Expanded Access Programs, compassionate drug use, and Emergency Use Authorizations during the COVID-19 pandemic.新冠肺炎大流行期间的扩大准入计划、同情用药和紧急使用授权。
Drug Discov Today. 2021 Feb;26(2):593-603. doi: 10.1016/j.drudis.2020.11.025. Epub 2020 Nov 27.
6
Association between alopecia areata, anxiety, and depression: A systematic review and meta-analysis.斑秃、焦虑和抑郁之间的关联:一项系统评价与荟萃分析。
J Am Acad Dermatol. 2023 May;88(5):1040-1050. doi: 10.1016/j.jaad.2019.05.086. Epub 2019 Jun 1.
7
Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis.巴瑞替尼:第二个获美国食品药品监督管理局批准用于治疗类风湿关节炎的 JAK 抑制剂。
Ann Pharmacother. 2019 Sep;53(9):947-953. doi: 10.1177/1060028019839650. Epub 2019 Mar 24.
8
The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature.《Janus 激酶抑制剂在斑秃中的应用:文献综述》。
J Cutan Med Surg. 2019 May/Jun;23(3):289-297. doi: 10.1177/1203475418824079. Epub 2019 Jan 28.
9
Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.斑秃:疾病特征、临床评估及发病机制的新观点。
J Am Acad Dermatol. 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141.
10
Alopecia Areata. Current situation and perspectives.斑秃。现状与展望。
Arch Argent Pediatr. 2017 Dec 1;115(6):e404-e411. doi: 10.5546/aap.2017.eng.e404.