Phung Huyen Thi, Nguyen Anh Quang, Van Nguyen Tung, Van Nguyen Trong, Nguyen Long Thanh, Nguyen Khuyen Thi, Thi Pham Ha Dieu
Department of Medical Oncology 6, Vietnam National Cancer Hospital, Hanoi, Viet Nam.
Department of Oncology, Vietnam University of Traditional Medicine, Hanoi, Viet Nam.
Ann Med Surg (Lond). 2022 Jul 16;80:104207. doi: 10.1016/j.amsu.2022.104207. eCollection 2022 Aug.
Ovarian metastasis from lung cancer is very rare, which might lead to a misdiagnosis as primary ovarian cancer.
We report a 49-year-old woman presenting to our hospital because of a painful mass in the lower abdomen, with no respiratory symptoms. Her initial diagnosis was stage IVB ovarian cancer with pulmonary metastasis. Therefore, the patient underwent neo-adjuvant Paclitaxel - Carbolatin chemotherapy followed by interval debulking surgery. However, postoperative histopathology and immunohistochemistry findings confirmed the diagnosis of primary lung cancer with ovarian metastases. EGFR exon 19 deletion mutation was found by tumor analysis. Therefore, she was then treated with erlotinib and the disease achieved the partial response and remained stable for 7 months.
Diagnosis of lung cancer in the context of ovarian and peritoneal metastases can be difficult. In this circumstance, thorough systemic assessment and immunohistochemistry are essential to confirm the primary.
肺癌的卵巢转移非常罕见，这可能导致误诊为原发性卵巢癌。
我们报告一名49岁女性因下腹部疼痛性肿块前来我院就诊，无呼吸道症状。她最初被诊断为伴有肺转移的IVB期卵巢癌。因此，患者接受了新辅助紫杉醇-卡铂化疗，随后进行了间隔减瘤手术。然而，术后组织病理学和免疫组化结果证实为原发性肺癌伴卵巢转移。通过肿瘤分析发现表皮生长因子受体（EGFR）外显子19缺失突变。因此，她随后接受了厄洛替尼治疗，疾病获得部分缓解并保持稳定7个月。
在存在卵巢和腹膜转移的情况下，肺癌的诊断可能具有挑战性。在这种情况下，全面的系统评估和免疫组化对于确定原发灶至关重要。
