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巴基斯坦的脊髓灰质炎:根除脊髓灰质炎面临的挑战及未来前景

Poliomyelitis in Pakistan: Challenges to polio eradication and future prospects.

作者信息

Shabbir Haroon, Saeed Sajeel, Farhan Muhammad, Abbas Khawar, Rehman Mohammad Ebad Ur, Gul Fahad, Basit Jawad

机构信息

Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.

Department of Surgery, Rawalpindi Medical University, Rawalpindi, Pakistan.

出版信息

Ann Med Surg (Lond). 2022 Jul 31;80:104274. doi: 10.1016/j.amsu.2022.104274. eCollection 2022 Aug.

DOI:10.1016/j.amsu.2022.104274
PMID:36045811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9422308/
Abstract

Poliomyelitis is a viral disease that causes acute paralysis, muscle weakness and autonomic dysfunction. It primarily affects children under the age of five. It is mainly transmitted via the feco-oral route, through contaminated water. As of the year 2022, Pakistan remains one of the two countries where polio is still endemic, the other being Afghanistan. Numerous myths and misconceptions regarding the polio vaccine, lack of awareness and proper governance, terrorism and difficult access to remote areas due to poor infrastructure are just some of the reasons why polio remains endemic in Pakistan to this day. Therefore, the government should take measures to ensure the safety and wellbeing of health care workers, as well as spread awareness regarding the importance of polio vaccines, while addressing the myths and misconception regarding said vaccines.

摘要

脊髓灰质炎是一种病毒性疾病,可导致急性瘫痪、肌肉无力和自主神经功能障碍。它主要影响五岁以下儿童。主要通过粪口途径,经受污染的水传播。截至2022年,巴基斯坦仍是脊髓灰质炎仍然流行的两个国家之一,另一个是阿富汗。关于脊髓灰质炎疫苗的众多神话和误解、缺乏认识和适当治理、恐怖主义以及由于基础设施差难以进入偏远地区,这些只是脊髓灰质炎至今在巴基斯坦仍然流行的部分原因。因此,政府应采取措施确保医护人员的安全和福祉,同时宣传脊髓灰质炎疫苗的重要性,并消除有关该疫苗的神话和误解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/9422308/43297f08c6bc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/9422308/43297f08c6bc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/9422308/43297f08c6bc/gr1.jpg

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本文引用的文献

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Eradicating polio in Pakistan: a systematic review of programs and policies.在巴基斯坦消灭小儿麻痹症:对项目和政策的系统评价。
Expert Rev Vaccines. 2021 Jun;20(6):661-678. doi: 10.1080/14760584.2021.1915139. Epub 2021 May 10.
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Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden.疫苗相关麻痹型脊髓灰质炎:流行病学综述及全球负担估计
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Complete genomic sequencing shows that polioviruses and members of human enterovirus species C are closely related in the noncapsid coding region.
以孤立性颈伸肌肌病为表现的小儿麻痹后遗症:一例报告
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Rebirth of the crippling illness: polio.致残疾病的重生:小儿麻痹症。
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Hum Vaccin Immunother. 2023 Dec 31;19(1):2173905. doi: 10.1080/21645515.2023.2173905. Epub 2023 Feb 20.
全基因组测序显示,脊髓灰质炎病毒与人类肠道病毒C种的成员在非衣壳编码区密切相关。
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