Moktan Varun P, Daoud Nader D, Tremaine William J, Loftus Edward V, Kane Sunanda V, Hochwald Alexander P, Hodge David O, Hashash Jana G, Faubion Stephanie S, Farraye Francis A
Division of Community Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.
Crohns Colitis 360. 2022 Aug 4;4(3):otac027. doi: 10.1093/crocol/otac027. eCollection 2022 Jul.
Menopause, defined by the complete cessation of menstrual cycles for 12 consecutive months, may occur at a younger age in women who have concomitant immune dysregulation. Our aim was to determine whether women with inflammatory bowel disease (IBD) experience an earlier onset of menopause compared to women without IBD.
This was a retrospective cohort study using resources of the Rochester Epidemiology Project, a collaboration between clinics, hospitals, and medical facilities in Olmsted County, Minnesota. From these people, women who were diagnosed with IBD between 1970 and 2010 comprised the case cohort while the reference cohort included women with no diagnosis of IBD. Data including age, body mass index (BMI), ethnicity, smoking status, age at onset of menopause, and current use of hormone therapy were collected. Patients with history of hysterectomy or oophorectomy were excluded. Wilcoxon rank-sum test for numeric variables and Fisher's exact test for categorical variables were used to analyze the data.
A total of 171 women met criteria for inclusion (83 cases and 88 controls). Mean age of menopause in women with IBD was 50.0 years compared to 51.5 years in women with no IBD ( = .006). There was no difference in BMI of women with and without IBD (28.7 versus 28.2 kg m; = .9), respectively. There were more former smokers (33.7%) and current (6%) smokers in the IBD group ( = .009) compared to the non-IBD group.
IBD is associated with an earlier onset of menopause. Although it is unclear if this mean difference of 1.5 years is clinically relevant, it is known that early menopause is associated with an increased risk of osteoporosis and cardiovascular disease. Further research on the possible mechanisms is needed.
绝经定义为月经周期连续停止12个月，在伴有免疫失调的女性中可能发生得更早。我们的目的是确定患有炎症性肠病（IBD）的女性与没有IBD的女性相比，绝经年龄是否更早。
这是一项回顾性队列研究，使用了罗切斯特流行病学项目的资源，该项目是明尼苏达州奥尔姆斯特德县的诊所、医院和医疗设施之间的合作项目。在这些人中，1970年至2010年间被诊断为IBD的女性组成病例队列，而对照队列包括未诊断为IBD的女性。收集的数据包括年龄、体重指数（BMI）、种族、吸烟状况、绝经年龄和目前激素治疗的使用情况。排除有子宫切除术或卵巢切除术病史的患者。使用数值变量的Wilcoxon秩和检验和分类变量的Fisher精确检验来分析数据。
共有171名女性符合纳入标准（83例病例和88例对照）。IBD女性的平均绝经年龄为50.0岁，而无IBD女性为51.5岁（P = 0.006）。有IBD和无IBD女性的BMI无差异（分别为28.7和28.2 kg/m²；P = 0.9）。与非IBD组相比，IBD组有更多既往吸烟者（33.7%）和当前吸烟者（6%）（P = 0.009）。
IBD与绝经年龄提前有关。虽然尚不清楚这1.5岁的平均差异是否具有临床相关性，但已知早绝经与骨质疏松症和心血管疾病风险增加有关。需要对可能的机制进行进一步研究。
