Fledelius H C, Petrera J E, Skjødt K, Trojaborg W
Acta Ophthalmol (Copenh). 1987 Apr;65(2):251-5. doi: 10.1111/j.1755-3768.1987.tb07008.x.
A 76-year-old female with ocular ethambutol toxicity prompted two investigations. Firstly, she was followed electrophysiologically, with multichannel recorded pattern reversal visual evoked potential techniques using full-field, half-field, central-field and peripheral field stimulation, plus flash VEP and ERG. The examinations performed 2, 5 and 7 months after ethambutol withdrawal indicated damage to the papillomacular bundle, while a late follow-up after recovery showed potentials of near normal configuration. Secondly an epidemiological survey was attempted based on the 37 ethambutol toxicity cases registered to the Danish Board on Adverse Reactions 1972-81, making up 1% of those receiving antituberculous therapy. They showed a significant preponderance of elderly (24/37 greater than 65 years) and of females (29/37). There was only one foreigner in the series. A detailed analysis of visual function in a subsample of 22 cases (those registered 1977-81) showed that visual impairment lasted several months, and that usually recovery was not complete. Using the visual demands for driver's license as criterium, 20 fulfilled the demands prior to therapy, but only 12 after recovery.
一名76岁女性出现眼部乙胺丁醇毒性反应，促使开展了两项调查。首先，对她进行了电生理跟踪，采用多通道记录模式翻转视觉诱发电位技术，使用全视野、半视野、中心视野和周边视野刺激，以及闪光视觉诱发电位和视网膜电图。在停用乙胺丁醇后2个月、5个月和7个月进行的检查显示乳头黄斑束受损，而恢复后的后期随访显示电位配置接近正常。其次，基于丹麦不良反应委员会1972年至1981年登记的37例乙胺丁醇毒性病例进行了一项流行病学调查，这些病例占接受抗结核治疗患者的1%。结果显示老年人（24/37大于65岁）和女性（29/37）明显居多。该系列中只有一名外国人。对22例病例（1977年至1981年登记的病例）的子样本进行的视觉功能详细分析表明，视力损害持续数月，而且通常恢复不完全。以驾照的视觉要求为标准，20人在治疗前符合要求，但恢复后只有12人符合要求。
