Zhang Huizhe, Shi Yanchen, Yi Qing, Wang Cong, Xia Qingqing, Zhang Yufeng, Jiang Weilong, Qi Jia
Department of Respiratory Medicine, Yancheng Hospital of Traditional Chinese Medicine, Yancheng Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, China.
Department of Pulmonary and Critical Care Medicine, Traditional Chinese and Western Medicine Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Front Genet. 2022 Aug 15;13:975185. doi: 10.3389/fgene.2022.975185. eCollection 2022.
Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease. Programmed cell death (PCD) performs an integral function in the origin and treatment of cancer. Some PCD-related effective signatures for predicting prognosis in LUAD patients could provide potential therapeutic options in LUAD. A copper-dependent cell death referred to as cuproptosis is distinct from known PCD. However, whether cuproptosis is associated with LUAD patients' prognoses and the potential roles of cuproptosis-related genes involved is still unknown. For the prediction of LUAD prognosis, we developed a unique cuproptosis-associated gene signature. In The Cancer Genome Atlas (TCGA) cohort, the score derived from the risk signature on the basis of six cuproptosis-related genes was found to independently serve as a risk factor for anticipating lung cancer-related death. The differentially expressed genes between the high- and low-risk groups were linked to the cilium-related function. LUAD patients' prognoses may now be predicted by a unique gene signature identified in this work. This discovery also provides a substantial foundation for future research into the links between cuproptosis-associated genes and cilium-related function in LUAD patients.
肺腺癌（LUAD）已成为原发性肺癌中最常见的组织学亚型，需要有效的创新预后模型来提高该疾病靶向治疗的可行性。程序性细胞死亡（PCD）在癌症的发生和治疗中发挥着不可或缺的作用。一些与PCD相关的有效特征可用于预测LUAD患者的预后，这可能为LUAD提供潜在的治疗选择。一种称为铜死亡的铜依赖性细胞死亡不同于已知的PCD。然而，铜死亡是否与LUAD患者的预后相关以及所涉及的铜死亡相关基因的潜在作用仍然未知。为了预测LUAD的预后，我们开发了一种独特的铜死亡相关基因特征。在癌症基因组图谱（TCGA）队列中，基于六个铜死亡相关基因的风险特征得出的分数被发现可独立作为预测肺癌相关死亡的风险因素。高风险组和低风险组之间的差异表达基因与纤毛相关功能有关。现在可以通过这项工作中确定的独特基因特征来预测LUAD患者的预后。这一发现也为未来研究LUAD患者中铜死亡相关基因与纤毛相关功能之间的联系提供了坚实的基础。
