Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China.
Department of Pharmacy, Daffodil International University, Dhanmondi-27, Dhaka, 1209, Bangladesh.
Eur J Pharmacol. 2021 Nov 5;910:174444. doi: 10.1016/j.ejphar.2021.174444. Epub 2021 Aug 26.
Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis has notably been gained extensive attention from clinicians and researchers. However, current studies report that downregulation of pyroptosis-mediated cell death plays a significant role in developing multiple cancers. Increasing studies also suggest that pyroptosis can impact all stages of carcinogenesis. Inducing pyroptotic cellular death could be a promising therapeutic option for managing and regulating multiple cancers in the near future. Our current review highlights the molecular and morphological features of pyroptosis and its potential roles in various cancers. In addition, we have also highlighted the biological characteristics and significances of GSDMD and GSDME and their critical functions in cancer progression, management and regulation.
细胞焦亡主要被认为是一种由gasdermin 调控的细胞死亡机制，其特征为细胞裂解和多种促炎因子的释放。如今，细胞焦亡已经引起了临床医生和研究人员的广泛关注。然而，目前的研究报告表明，细胞焦亡介导的细胞死亡下调在多种癌症的发生发展中起着重要作用。越来越多的研究还表明，细胞焦亡可以影响癌症发生的所有阶段。诱导细胞焦亡性细胞死亡可能是未来管理和调节多种癌症的一种很有前途的治疗选择。我们目前的综述强调了细胞焦亡的分子和形态特征及其在各种癌症中的潜在作用。此外，我们还强调了 GSDMD 和 GSDME 的生物学特性和意义及其在癌症进展、管理和调控中的关键作用。
