Jarad Suha, Akour Amal, Khreisat Wael H, Elshammari Afrah K, Madae'en Saba
Department of Clinical Pharmacy and Biopharmaceutics, School of Pharmacy, The University of Jordan, Amman, Jordan.
Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
J Pharm Technol. 2022 Oct;38(5):272-282. doi: 10.1177/87551225221097619. Epub 2022 Jul 19.
Rate of nonadherence to antiepileptic drugs (AEDs) in children is about 33%. Engaging clinical pharmacists in the management of patients has proved to increase adherence to medications which will improve the outcomes of treatment.
To investigate the effect of a clinical pharmacist-led education on the adherence to AEDs in pediatric patients with epilepsy. Secondary outcomes include effectiveness and safety of AEDs, satisfaction with information about AEDs provided to the caregivers, and patients quality of life (QoL).
This was an interventional study where pediatric patients were randomly assigned to the intervention (n = 41) or the control (n = 40) group. A 30-minute clinical pharmacist-led educational interview to the parent/caregiver was provided to the first group as add-on to standard medical care received by latter. Outcomes were measured at baseline and after 8-week follow-up.
The intervention group had an increase in mean adherence score from 6 ± 1.09 at baseline to 7.6 ± 0.9 at follow-up ( value < 0.001), while the control group had no significant change ( value > 0.05), the difference between the 2 groups at follow-up was significant ( value < 0.0001). No significant difference was observed between groups at follow-up with regard to effectiveness ( value > 0.05), and safety ( value = 0.08). While higher satisfaction with information ( value < 0.0001), and higher QoL ( value < 0.05) was observed in the intervention group.
Clinical pharmacist-led education had a positive outcome on pediatric patients with epilepsy with regard to adherence, effectiveness, safety, satisfaction with information about AEDs, and QoL.
儿童抗癫痫药物（AEDs）的不依从率约为33%。事实证明，让临床药师参与患者管理可提高药物依从性，从而改善治疗效果。
研究临床药师主导的教育对癫痫患儿服用AEDs依从性的影响。次要结果包括AEDs的有效性和安全性、对提供给护理人员的AEDs信息的满意度以及患者的生活质量（QoL）。
这是一项干预性研究，将儿科患者随机分为干预组（n = 41）或对照组（n = 40）。作为后者接受的标准医疗护理的补充，为第一组的家长/护理人员提供了一次由临床药师主导的30分钟教育访谈。在基线和8周随访后测量结果。
干预组的平均依从性评分从基线时的6±1.09增加到随访时的7.6±0.9（P值<0.001），而对照组无显著变化（P值>0.05），两组在随访时的差异具有统计学意义（P值<0.0001）。随访时两组在有效性（P值>0.05）和安全性（P值 = 0.08）方面无显著差异。而干预组对信息的满意度更高（P值<0.0001），生活质量也更高（P值<0.05）。
临床药师主导的教育在依从性、有效性、安全性、对AEDs信息的满意度以及生活质量方面对癫痫患儿产生了积极影响。
