Tran Manh Tien
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan.
Explor Target Antitumor Ther. 2021;2(3):249-265. doi: 10.37349/etat.2021.00045. Epub 2021 Jun 28.
Intracellular Ca ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of fundamental cellular physiology such as gene expression, cell division, cell motility and apoptosis. It has been suggestive of the Ca signaling-dependent cellular processes to be tightly regulated by the numerous types of Ca channels, pumps, exchangers and sensing receptors. Consequently, dysregulated Ca homeostasis leads to a series of events connected to elevated malignant phenotypes including uncontrolled proliferation, migration, invasion and metastasis, all of which are frequently observed in advanced stage lung cancer cells. The incidence of bone metastasis in patients with advanced stage lung cancer is estimated in a range of 30% to 40%, bringing about a significant negative impact on both morbidity and survival. This review dissects and summarizes the important roles of Ca signaling transduction in contributing to lung cancer progression, and address the question: if and how Ca signaling might have been engaged in metastatic lung cancer with bone metastasis, thereby potentially providing the multifaceted and promising solutions for therapeutic intervention.
细胞内钙离子被认为是细胞信号传导中最重要的第二信使之一，在调节众多基本细胞生理过程中发挥着多种多样的作用，如基因表达、细胞分裂、细胞运动和细胞凋亡。这表明依赖钙信号的细胞过程受到多种类型的钙通道、泵、交换器和传感受体的严格调控。因此，钙稳态失调会导致一系列与恶性表型升高相关的事件，包括不受控制的增殖、迁移、侵袭和转移，所有这些在晚期肺癌细胞中都经常观察到。晚期肺癌患者骨转移的发生率估计在30%至40%之间，对发病率和生存率都产生了重大负面影响。本综述剖析并总结了钙信号转导在肺癌进展中的重要作用，并探讨了以下问题：钙信号是否以及如何参与伴有骨转移的转移性肺癌，从而有可能为治疗干预提供多方面且有前景的解决方案。
