Gallini Francesca, De Rose Domenico Umberto, Coppola Maria, Pelosi Maria Sofia, Cota Francesco, Bottoni Anthea, Ricci Daniela, Romeo Domenico Marco, Spanu Teresa, Maggio Luca, Mercuri Eugenio, Vento Giovanni
Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Università Cattolica del Sacro Cuore, Milan, Italy.
Front Pediatr. 2022 Aug 15;10:893812. doi: 10.3389/fped.2022.893812. eCollection 2022.
(.) and (.) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infants born to mothers with / colonization during pregnancy.
Preterm infants with gestational age (GA) of ≤ 30 weeks were included in a retrospective follow-up study. To evaluate the effects of maternal vaginal colonization, we divided preterm infants into two groups: exposed and unexposed infants. All infants were assessed at 24 ± 3 months of age using Griffith's Mental Developmental Scales (GMDS).
Among 254 preterm infants, only 32 infants (12.6%) were exposed to U. /M. colonization during pregnancy. Exposed infants and unexposed ones had a similar Griffith's Developmental Quotient (106 ± 27.2 vs. 108.9 ± 19.5, respectively), without significant differences ( = 0.46). However, exposed infants had a significantly poorer outcome than their unexposed peers in terms of locomotor abilities (100.7 ± 28.3 exposed vs. 111.5 ± 26.1 unexposed, = 0.03).
For visual and hearing impairment, exposed and unexposed infants had similar incidences of cognitive and motor impairment. However, exposed infants had significantly lower locomotor scores than unexposed peers.
（.）和（.）菌种与妊娠并发症（包括早产）及更差的新生儿结局有关。我们这项研究的目的是评估孕期母亲有/定植的早产婴儿的神经发育结局。
将孕周（GA）≤30周的早产婴儿纳入一项回顾性随访研究。为评估母亲阴道定植的影响，我们将早产婴儿分为两组：暴露组和未暴露组。所有婴儿在24±3月龄时使用格里菲斯心理发育量表（GMDS）进行评估。
在254名早产婴儿中，只有32名婴儿（12.6%）在孕期暴露于/定植。暴露组婴儿和未暴露组婴儿的格里菲斯发育商相似（分别为106±27.2和108.9±19.5），无显著差异（=0.46）。然而，在运动能力方面，暴露组婴儿的结局明显比未暴露组婴儿差（暴露组为100.7±28.3，未暴露组为111.5±26.1，=0.03）。
对于视力和听力障碍，暴露组和未暴露组婴儿的认知和运动障碍发生率相似。然而，暴露组婴儿的运动得分明显低于未暴露组婴儿。
