Rittenschober-Böhm Judith, Habermüller Tanja, Waldhoer Thomas, Fuiko Renate, Schulz Stefan M, Pimpel Birgit, Goeral Katharina, Witt Armin, Berger Angelika, Pichler Karin
Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Department of Epidemiology, Center of Public Health, Medical University of Vienna, 1090 Vienna, Austria.
Children (Basel). 2021 Apr 3;8(4):276. doi: 10.3390/children8040276.
Vaginal colonization with () spp. has been shown to be associated with adverse pregnancy outcome; however, data on neonatal outcome are scarce. The aim of the study was to investigate whether maternal vaginal colonization with spp. in early pregnancy represents a risk factor for adverse short- or long-term outcome of preterm infants. Previously, 4330 pregnant women were enrolled in an observational multicenter study, analyzing the association between vaginal spp. colonization and spontaneous preterm birth. spp. colonization was diagnosed via PCR analysis from vaginal swabs. For this study, data on short-term outcome were collected from medical records and long-term outcome was examined via Bayley Scales of Infant Development at 24 months adjusted age. Two-hundred-and-thirty-eight children were born <33 weeks gestational age. After exclusion due to asphyxia, malformations, and lost-to-follow-up, data on short-term and long-term outcome were available from 222 and 92 infants, respectively. Results show a significant association between vaginal spp. colonization and severe intraventricular hemorrhage (10.4% vs. 2.6%, = 0.03), retinopathy of prematurity (21.7% vs. 10.3%, = 0.03), and adverse psychomotor outcome (24.3% vs. 1.8%, OR 13.154, 95%CI 1.6,110.2, = 0.005). The data suggest an association between vaginal spp. colonization in early pregnancy and adverse short- and long-term outcome of very preterm infants.
已证明阴道被[]菌属定植与不良妊娠结局相关；然而，关于新生儿结局的数据却很稀少。本研究的目的是调查孕早期孕妇阴道被[]菌属定植是否是早产婴儿短期或长期不良结局的危险因素。此前，4330名孕妇参与了一项观察性多中心研究，分析阴道[]菌属定植与自发性早产之间的关联。通过对阴道拭子进行PCR分析来诊断[]菌属定植。在本研究中，短期结局数据从病历中收集，长期结局则通过在矫正年龄24个月时的贝利婴儿发育量表进行检查。238名儿童在孕龄<33周时出生。在排除窒息、畸形和失访因素后，分别有222名和92名婴儿的短期和长期结局数据可用。结果显示，阴道[]菌属定植与严重脑室内出血（10.4%对2.6%，P = 0.03）、早产儿视网膜病变（21.7%对10.3%，P = 0.03）以及不良精神运动发育结局（24.3%对1.8%，OR 13.154，95%CI 1.6,110.2，P = 0.005）之间存在显著关联。数据表明，孕早期阴道[]菌属定植与极早产儿的短期和长期不良结局之间存在关联。
