Cai Jia-Jia, Ying Jin-Jing, Li Jing-Hua
Department of Pediatrics, Yuyao People's Hospital Yuyao 315400, Zhejiang, China.
Am J Transl Res. 2024 Dec 15;16(12):7222-7237. doi: 10.62347/YQIQ1947. eCollection 2024.
(UU) is an opportunistic pathogen transmitted from mother to fetus, potentially causing neonatal diseases. Despite extensive research, its association with these diseases remains uncertain. This study analyzes the effects of UU infection on newborns.
We performed an exhaustive literature review by searching various databases, including PubMed, EMBASE, and Cochrane, for research articles published before March 2024 on the impact of UU infection on neonates and its association with related diseases. Keywords included "", "Pregnancy Outcomes", "Sepsis", "Cerebral Intraventricular Hemorrhage", "Bronchopulmonary Dysplasia", and "Necrotizing Enterocolitis". Two authors independently screened the literature, extracted data, and evaluated study quality. Meta-analysis was conducted using Stata software, where either a fixed-effects model or a random-effects model was employed to calculate the odds ratio (OR) and 95% confidence interval (CI). The methodological quality of each study was assessed, and the quality of evidence for outcome measures was graded using the GRADE (Grades of Recommendations Assessment, Development and Evaluation, GRADE) system.
Thirteen studies, published between 2011 and 2024, were included, covering regions of China (two studies), South Korea (three studies), Japan (two studies), Austria (three studies), Germany (one study), Belgium (one study), and Italy (one study). Findings indicate that UU infection significantly increased the risk of bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and sepsis in neonates. However, the correlation between UU infection and necrotizing enterocolitis (NEC) was found not to be significant. Additionally, a descriptive analysis of two studies on UU infection's impact on neonatal pneumonia showed no significant correlation.
UU infection significantly increases the risk of BPD, IVH, and sepsis in newborns.
解脲脲原体（UU）是一种可通过母婴传播的机会性致病菌，可能导致新生儿疾病。尽管已进行了广泛研究，但其与这些疾病的关联仍不明确。本研究分析了UU感染对新生儿的影响。
我们通过检索包括PubMed、EMBASE和Cochrane在内的多个数据库，对2024年3月之前发表的关于UU感染对新生儿的影响及其与相关疾病关联的研究文章进行了详尽的文献综述。关键词包括“”“妊娠结局”“败血症”“脑室内出血”“支气管肺发育不良”和“坏死性小肠结肠炎”。两名作者独立筛选文献、提取数据并评估研究质量。使用Stata软件进行荟萃分析，采用固定效应模型或随机效应模型计算比值比（OR）和95%置信区间（CI）。评估每项研究的方法学质量，并使用GRADE（推荐分级评估、制定与评价）系统对结局指标的证据质量进行分级。
纳入了2011年至2024年发表的13项研究，涵盖中国（2项研究）、韩国（3项研究）、日本（2项研究）、奥地利（3项研究）、德国（1项研究）、比利时（1项研究）和意大利（1项研究）等地区。研究结果表明，UU感染显著增加了新生儿支气管肺发育不良（BPD）、脑室内出血（IVH）和败血症的风险。然而，发现UU感染与坏死性小肠结肠炎（NEC）之间无显著相关性。此外，对两项关于UU感染对新生儿肺炎影响的研究进行的描述性分析显示无显著相关性。
UU感染显著增加新生儿发生BPD、IVH和败血症的风险。
