Chen Huadong, Xu Xing'e, Peng Jiren, Ge Xuan, Zhang Jing'an, Dong Qianqian, Jiang Xiunan, Li Piaopiao
Department of Pharmacy, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, People's Republic of China.
Department of Vasculocardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, People's Republic of China.
Patient Prefer Adherence. 2022 Aug 25;16:2345-2352. doi: 10.2147/PPA.S374808. eCollection 2022.
Adherence to warfarin is associated with improved outcome in patients with atrial fibrillation (AF), but the adherence status of patients in rural areas of China is not known.
A questionnaire-based study evaluating warfarin adherence of rural residents with AF was carried out in Dongyang, China. Potentially eligible patients were screened and contacted by telephone, and their demographic characteristics were collected. Illness perception was assessed using the Brief Illness Perception Questionnaire (BIPQ), and warfarin adherence was assessed using a Chinese-version adherence scale. Univariate and multivariate analyses were conducted to identify factors associated with unsatisfactory adherence.
A total of 201 patients (male, =99; mean age, 70.3±8.12 years) were included, among whom 95 (47.3%) patients showed good adherence and 63 (31.3%) poor adherence. Number of co-dispensed drugs (multivariate analysis: odds ratio [OR]=3.64, 95% confidence interval [CI] 1.35-9.81, =0.011) and BIPQ score (OR=1.25, 95% CI 1.17-1.33, <0.001) were identified as factors associated with good adherence.
Medical adherence to warfarin needs to improve in rural patients with AF. Efforts that can reduce the number of co-dispensed drugs and increase illness perception may improve warfarin adherence. This study may benefit future management of warfarin administration to rural patients with AF.
房颤（AF）患者对华法林的依从性与改善预后相关，但中国农村地区患者的依从性状况尚不清楚。
在中国东阳开展了一项基于问卷的研究，以评估农村房颤居民对华法林的依从性。通过电话筛选并联系潜在符合条件的患者，收集他们的人口统计学特征。使用简明疾病感知问卷（BIPQ）评估疾病感知，使用中文版依从性量表评估华法林依从性。进行单因素和多因素分析以确定与依从性不佳相关的因素。
共纳入201例患者（男性99例；平均年龄70.3±8.12岁），其中95例（47.3%）患者依从性良好，63例（31.3%）患者依从性差。联合配药数量（多因素分析：比值比[OR]=3.64，95%置信区间[CI]1.35 - 9.81，P=0.011）和BIPQ评分（OR=1.25，95%CI 1.17 - 1.33，P<0.001）被确定为与良好依从性相关的因素。
农村房颤患者对华法林的药物依从性有待提高。减少联合配药数量并增强疾病感知的措施可能会改善华法林依从性。本研究可能有助于未来对农村房颤患者进行华法林给药管理。
