Al-Saikhan F I
Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Niger J Clin Pract. 2020 Mar;23(3):398-407. doi: 10.4103/njcp.njcp_608_18.
Treatment satisfaction and medication adherence to oral anticoagulant therapy are important measures that often decrease morbidity and mortality. Though warfarin is a frequently prescribed oral anticoagulant, warfarin therapy adherence (WTA) and its impact on overall Health-Related Quality of Life (HRQoL) has not been studied in Saudi Arabia.
To assess the association between WTA and HRQoL among patients on warfarin in Saudi Arabia.
A prospective, cross-sectional, descriptive study was conducted on 387 patients on warfarin therapy attending an outpatient anticoagulation clinic in Alkharj, Saudi Arabia. WTA was assessed using medication adherence measuring scale (MAMS) whereas HRQoL was measured using World Health Organization QOL-BREF (WHOQOL-BREF). Descriptive and inferential statistics were used to examine patients' demographic characteristics and to determine the association among different variables. Spearman's correlation coefficient was used to determine the association between various study variables.
Of the total 387 participants, there were more females than males (n=257, 66.4%, and n=130, 33.6% respectively). The mean adherence score for the study population was 5.86±1.21. Mean HRQoL score for physical health domain, psychological domain, social relationships domain, and environment domain were 62.11±15.53, 68.20±16.11, 64.46±26.19 and 63.43±17.60 respectively. The correlation coefficients for all the four domains of the WHOQOL-BREF vs total mean score of warfarin therapy adherence were 0.124, 0.051, 0.063 and 0.083 respectively indicating a weak positive association between warfarin therapy adherence and physical health domain (P < 0.005). Study results indicate a positive association between WTA and the physical health domain of the WHOQOL-BREF among patients on warfarin.
Better warfarin therapy adherence can improve the physical health of patients on warfarin.
治疗满意度和口服抗凝治疗的药物依从性是重要指标，通常可降低发病率和死亡率。尽管华法林是常用的口服抗凝剂，但在沙特阿拉伯尚未对华法林治疗依从性（WTA）及其对总体健康相关生活质量（HRQoL）的影响进行研究。
评估沙特阿拉伯接受华法林治疗的患者中WTA与HRQoL之间的关联。
对沙特阿拉伯阿尔卡吉一家门诊抗凝诊所的387例接受华法林治疗的患者进行了一项前瞻性、横断面描述性研究。使用药物依从性测量量表（MAMS）评估WTA，而使用世界卫生组织生活质量简表（WHOQOL-BREF）测量HRQoL。描述性和推断性统计用于检查患者的人口统计学特征，并确定不同变量之间的关联。Spearman相关系数用于确定各种研究变量之间的关联。
在总共387名参与者中，女性多于男性（分别为n = 257，66.4%和n = 130，33.6%）。研究人群的平均依从性得分为5.86±1.21。身体健康领域、心理领域、社会关系领域和环境领域的平均HRQoL得分分别为62.11±15.53、68.20±16.11、64.46±26.19和63.43±17.60。WHOQOL-BREF所有四个领域与华法林治疗依从性总平均分的相关系数分别为0.124、0.051、0.063和0.083，表明华法林治疗依从性与身体健康领域之间存在弱正相关（P < 0.005）。研究结果表明，在接受华法林治疗的患者中，WTA与WHOQOL-BREF的身体健康领域之间存在正相关。
更好的华法林治疗依从性可改善接受华法林治疗患者的身体健康。
