Radwan Loubna M, Bou Ghanem Ghazi O, Daye Ghassan N, Ghazi Nicola G
LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
Eye Institute, Cleveland Clinic Abu Dhabi, United Arab Emirates, 59 Hamouda Bin Ali Dhaheri St- Jazeerat Al Maryah- Abu Dhabi, United Arab Emirates.
Am J Ophthalmol Case Rep. 2022 Aug 18;28:101687. doi: 10.1016/j.ajoc.2022.101687. eCollection 2022 Dec.
to report a case of acute macular neuroretinopathy occurring after intravitreal aflibercept injection for macular edema due to CRVO.
Two days after Aflibercept intravitreal injection, the patient developed vision loss associated with a central scotoma. Optical coherence tomography showed a hyperreflective band at the level of the outer nuclear/outer plexiform layer corresponding to the patient's scotoma, ruling in the diagnosis of acute macular neuroretinopahty. Even though the OCT abnormalities resolved spontaneously, only partial resolution of the scotoma was observed 4 months later.
Acute macular neuroretinopathy might be associated with intravitreal anti-VEGF injection.
报告1例因视网膜中央静脉阻塞（CRVO）导致黄斑水肿，在玻璃体内注射阿柏西普后发生急性黄斑神经视网膜病变的病例。
玻璃体内注射阿柏西普两天后，患者出现与中心暗点相关的视力丧失。光学相干断层扫描显示，在外核层/外丛状层水平有一条高反射带，与患者的暗点相对应，从而确诊为急性黄斑神经视网膜病变。尽管光学相干断层扫描异常情况自发消退，但4个月后仅观察到暗点部分消退。
急性黄斑神经视网膜病变可能与玻璃体内抗血管内皮生长因子（VEGF）注射有关。
