Wheatley H Matthew, Sarraf David
*Department of Ophthalmology, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey; †NJ Retina, New Brunswick, New Jersey; ‡Stein Eye Institute, UCLA, Los Angeles, California; and §Greater Los Angeles VA Healthcare Center, Los Angeles California.
Retin Cases Brief Rep. 2017;11 Suppl 1:S148-S150. doi: 10.1097/ICB.0000000000000386.
To report a case of acute macular neuroretinopathy occurring after intravitreal ranibizumab injection for diabetic macular edema.
Observational clinical case report.
The patient received an intravitreal ranibizumab (0.3 mg) injection for diabetic macular edema. Three days later, he had a decline in vision associated with a central and paracentral scotoma. Optical coherence tomography (OCT) demonstrated bandlike hyperreflectivity of the outer nuclear and plexiform layers corresponding to the patient's scotoma, consistent with the diagnosis of acute macular neuroretinopathy. There was spontaneous resolution of the abnormalities observed in optical coherence tomography, but only partial resolution of the scotoma was observed 4 months after presentation.
Diabetic retinopathy may be associated with acute macular neuroretinopathy. The temporal relationship between ranibizumab injection and the onset of acute macular neuroretinopathy in this case report raises the possibility of a causal relationship.
报告1例玻璃体内注射雷珠单抗治疗糖尿病性黄斑水肿后发生急性黄斑神经视网膜病变的病例。
观察性临床病例报告。
该患者因糖尿病性黄斑水肿接受玻璃体内注射雷珠单抗（0.3mg）。三天后，他出现视力下降并伴有中心和旁中心暗点。光学相干断层扫描（OCT）显示与患者暗点相对应的外核层和神经丛层呈带状高反射，符合急性黄斑神经视网膜病变的诊断。光学相干断层扫描观察到的异常有自发消退，但在出现症状4个月后仅观察到暗点部分消退。
糖尿病视网膜病变可能与急性黄斑神经视网膜病变有关。本病例报告中雷珠单抗注射与急性黄斑神经视网膜病变发作之间的时间关系增加了因果关系的可能性。
