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蝎毒组分对……速殖子的抑制作用

Inhibitory Effect of Scorpion Venom Fractions on Tachyzoites of .

作者信息

Khaleghi Rostamkolaie Lida, Hamidinejat Hossein, Razi Jalali Mohammad Hossein, Najafzadeh Varzi Hossein, Seifi Abadshapouri Massoud Reza, Jafari Hedieh

机构信息

Department of Parasitology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Department of Pharmacology, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.

出版信息

Iran J Parasitol. 2022 Jan-Mar;17(1):79-89. doi: 10.18502/ijpa.v17i1.9019.

DOI:10.18502/ijpa.v17i1.9019
PMID:36046559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9375715/
Abstract

BACKGROUND

The present study determined the effect of the fractions obtained from scorpion venom on the tachyzoite of .

METHODS

The fractions of dried venom of scorpion of Khuzestan Province, southern Iran in 2019 were isolated through gel filtration chromatography, and then tachyzoites were exposed to fractions of venom at different concentrations. Trypan blue counting and MTT were applied to assay tachyzoite viability, and the inhibition of the cellular growth of fractions in Vero cells was evaluated.

RESULTS

The maximum effect on tachyzoite was observed in fraction 5 of venom. To further separate the protein, fraction 5 was used in high-performance liquid chromatography assay to purify its proteins. Based on the results of HPLC of fraction 5, among which the second peak, a peptide with <10 KDa representing a more potent effect in eliminating the tachyzoite of .

CONCLUSION

The scorpion venom-purified fractions possess anti-parasitic activity against the tachyzoite of and can be used in parasite-controlling studies.

摘要

背景

本研究确定了从蝎毒中获得的组分对[某种寄生虫]速殖子的影响。

方法

2019年，通过凝胶过滤色谱法分离伊朗南部胡齐斯坦省蝎子干毒的组分，然后将速殖子暴露于不同浓度的毒液组分中。应用台盼蓝计数和MTT法检测速殖子活力，并评估各组分对Vero细胞生长的抑制作用。

结果

在毒液的组分5中观察到对速殖子的最大作用。为进一步分离蛋白质，将组分5用于高效液相色谱分析以纯化其蛋白质。基于组分5的高效液相色谱结果，其中第二个峰，一种分子量小于10 kDa的肽在消除[某种寄生虫]速殖子方面表现出更强的作用。

结论

蝎毒纯化组分对[某种寄生虫]速殖子具有抗寄生虫活性，可用于寄生虫控制研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/f35bc71080a8/IJPA-17-79-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/2b19b197f6ca/IJPA-17-79-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/ebe2b2a08473/IJPA-17-79-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/cf8b89507683/IJPA-17-79-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/1d106dc3bddb/IJPA-17-79-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/012d00bb7bdf/IJPA-17-79-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/b5f076d7186f/IJPA-17-79-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/f35bc71080a8/IJPA-17-79-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/2b19b197f6ca/IJPA-17-79-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/ebe2b2a08473/IJPA-17-79-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/cf8b89507683/IJPA-17-79-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/1d106dc3bddb/IJPA-17-79-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/012d00bb7bdf/IJPA-17-79-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/b5f076d7186f/IJPA-17-79-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ae4/9375715/f35bc71080a8/IJPA-17-79-g007.jpg

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