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机器人辅助肾部分切除术整块切除肾静脉血栓治疗多发cT3a期肾细胞癌病灶

Robotic Partial Nephrectomy with En Bloc Removal of a Renal Vein Thrombus for Multiple cT3a Renal Cell Carcinoma Lesions.

作者信息

Grosso Antonio Andrea, Marìn Diego Marcos, Di Maida Fabrizio, Gallo Maria Lucia, Lambertini Luca, Nardoni Samuele, Mari Andrea, Minervini Andrea

机构信息

Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy.

Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

出版信息

Eur Urol Open Sci. 2022 Aug 22;44:33-36. doi: 10.1016/j.euros.2022.08.002. eCollection 2022 Oct.

Abstract

UNLABELLED

Partial nephrectomy (PN) may be recommended for selected patients with advanced-stage (>cT2) renal cell carcinoma (RCC) with the aim of avoiding dialysis and chronic kidney disease-related comorbidities. The spread of robotic surgery has led to expansion of PN indications to more challenging scenarios and even frontier surgeries, including advanced-stage RCC. Here we describe the management of a patient with a solitary kidney diagnosed with multiple cT3a (renal vein thrombus) RCC who was treated using a conservative robotic approach. The most crucial surgical considerations for this procedure were: (1) tailored planning of the surgical approach using three-dimensional reconstruction software; (2) accurate boundary delineation for the tumors and thrombus; (3) avoiding unnecessary warm ischemia time; (4) performing an anatomical excision to follow eventual tumor bulging; and (5) en bloc removal of the main lesion and its thrombus. No perioperative complications were recorded. Histopathology revealed clear cell RCC for all four lesions with nucleolar grade 3 and negative surgical margins. At 12-mo follow-up the patient was disease-free. When performed by an experienced surgeon, PN plus venous thrombus excision for imperative cases with cT3 RCC may represent a valid treatment option with valuable oncological and functional outcomes.

PATIENT SUMMARY

We describe the case of patient who had a single kidney with multiple kidney tumors and tumor extension into a blood vessel. The patient was treated with robot-assisted removal of the tumors, sparing as much kidney tissue as possible. This technique was found to be safe and effective, with no complications and good intermediate-term results.

摘要

未标注

对于部分晚期(>cT2)肾细胞癌(RCC)患者,可考虑行保留肾单位手术(PN),目的是避免透析及慢性肾脏病相关的合并症。机器人手术的普及使得PN的适应证扩展到更具挑战性的情况甚至前沿手术,包括晚期RCC。在此,我们描述了一名诊断为多发cT3a(肾静脉血栓)RCC的单肾患者采用保守机器人手术方法的治疗过程。该手术最关键的手术要点包括:(1)使用三维重建软件定制手术入路规划;(2)准确划定肿瘤和血栓的边界;(3)避免不必要的热缺血时间;(4)进行解剖性切除以适应最终的肿瘤隆起;(5)整块切除主要病变及其血栓。未记录到围手术期并发症。组织病理学显示所有四个病变均为透明细胞RCC,核分级为3级,手术切缘阴性。随访12个月时患者无疾病复发。对于有经验的外科医生而言,对于cT3 RCC的必要病例行PN加静脉血栓切除术可能是一种有效的治疗选择,具有有价值的肿瘤学和功能学结果。

患者总结

我们描述了一名单肾且患有多个肾肿瘤且肿瘤侵犯血管的患者的病例。该患者接受了机器人辅助肿瘤切除术,尽可能保留了肾组织。结果发现该技术安全有效,无并发症且中期效果良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9925/9421307/b41a3cb944f5/gr1.jpg

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