Herin P, Zetterström R
Acta Paediatr Scand. 1987 May;76(3):447-52. doi: 10.1111/j.1651-2227.1987.tb10497.x.
The renal effects of two diets--breast-milk and breast-milk with extra human protein (7 g/l breast-milk)--were compared in very low birth weight infants with a gestational age of 26 to 30 weeks. When the infants were given the high protein diet for one week the glomerular filtration rate (GFR) increased significantly more than when breast-milk alone was given. Sodium clearance showed a similar increase in proportion to the GFR during the two diets. The high protein diet raised the urine osmolality moderately in all individuals, while the diuresis remained unchanged. The data in the present study indicate that the function of the immature kidney is influenced by the amount of protein in the diet. However, the long-term renal effects in preterm infants maintained on a high protein intake remain unknown.
在胎龄为26至30周的极低出生体重婴儿中，比较了两种饮食——母乳和添加额外人乳蛋白（每升母乳含7克）的母乳——对肾脏的影响。当给婴儿喂食高蛋白饮食一周时，肾小球滤过率（GFR）的增加显著高于仅喂食母乳时。在两种饮食期间，钠清除率与GFR成比例地出现类似增加。高蛋白饮食使所有个体的尿渗透压适度升高，而尿量保持不变。本研究中的数据表明，未成熟肾脏的功能受饮食中蛋白质含量的影响。然而，长期摄入高蛋白对早产儿肾脏的影响仍不清楚。
