酶催化的烯丙基氧化反应：一篇综述短文
Enzyme-catalyzed allylic oxidation reactions: A mini-review.
作者信息
Wang Maoyao, Zhou Xiaojian, Wang Zhongqiang, Chen Yongzheng
机构信息
Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China.
Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.
出版信息
Front Chem. 2022 Aug 15;10:950149. doi: 10.3389/fchem.2022.950149. eCollection 2022.
Chiral allylic oxidized products play an increasingly important role in the pharmaceutical, agrochemical, and pharmaceutical industries. Biocatalytic C-H oxyfunctionalization to synthesize allylic oxidized products has attracted great attention in recent years, with the ability to simplify synthetic approaches toward complex compounds. As a result, scientists have found some new enzymes and mutants through techniques of gene mining and enzyme-directed evolution in recent years. This review summarizes the recent developments in biocatalytic selective oxidation of olefins by different kinds of biocatalysts.
手性烯丙基氧化产物在制药、农用化学品和医药行业中发挥着越来越重要的作用。近年来，生物催化C-H氧官能化合成烯丙基氧化产物因其能够简化复杂化合物的合成方法而备受关注。因此，近年来科学家们通过基因挖掘和酶定向进化技术发现了一些新的酶和突变体。本文综述了不同类型生物催化剂对烯烃进行生物催化选择性氧化的研究进展。
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