Chang E S
Acta Pathol Jpn. 1987 Feb;37(2):213-24. doi: 10.1111/j.1440-1827.1987.tb03057.x.
Electron microscopic studies of 53 diagnostic liver biopsies from 23 patients were done. Ultrastructural study revealed most striking alteration to be in the mitochondria such as pleomorphism in shape and size, especially giant mitochondria with disorganization, crystalline inclusions and calcium-like electron dense bodies. These ultrastructural changes might have been induced by specific biochemical abnormality in alcohol bearing condition. Diagnostic use of electron microscopy will be useful in detecting alcoholic injury in alcoholic patient who fails to demonstrate any discernible laboratory and light microscopic abnormalities.
对23例患者的53份诊断性肝活检标本进行了电子显微镜研究。超微结构研究显示，最显著的改变发生在线粒体，表现为形状和大小的多形性，尤其是巨大线粒体，伴有结构紊乱、晶体包涵体和类钙电子致密体。这些超微结构变化可能是由饮酒状态下的特定生化异常引起的。电子显微镜的诊断应用将有助于检测那些在实验室检查和光学显微镜检查中未发现明显异常的酒精性肝病患者的酒精性损伤。
