Can a Banana a Day Keep the Cancer Away in Patients with Lynch Syndrome?

The CAPP2 investigators report on the long-term effects of resistant starch (RS) on the incidence of colorectal cancer and other Lynch syndrome-related tumors in the trial population of the CAPP-2 study. RS has no effect on colorectal cancer incidence, but it reduced the numbers of other Lynch syndrome-related tumors, mainly driven by upper gastrointestinal cancers. Although the study has limitations related to secondary analysis, it fills an important void in the field of cancer interception of non-colorectal Lynch syndrome-related tumors and should form the basis for future trials of RS in Lynch syndrome. See related article, p. 623.