Bansal Ajay, Montgomery Robert, Vilar Eduardo
Division of Gastroenterology and Hepatology, The University of Kansas Medical Center, Kansas City, Kansas.
The University of Kansas Cancer Center, Kansas City, Kansas.
Cancer Prev Res (Phila). 2022 Sep 1;15(9):557-559. doi: 10.1158/1940-6207.CAPR-22-0312.
The CAPP2 investigators report on the long-term effects of resistant starch (RS) on the incidence of colorectal cancer and other Lynch syndrome-related tumors in the trial population of the CAPP-2 study. RS has no effect on colorectal cancer incidence, but it reduced the numbers of other Lynch syndrome-related tumors, mainly driven by upper gastrointestinal cancers. Although the study has limitations related to secondary analysis, it fills an important void in the field of cancer interception of non-colorectal Lynch syndrome-related tumors and should form the basis for future trials of RS in Lynch syndrome. See related article, p. 623.
CAPP2研究的调查人员报告了抗性淀粉（RS）对CAPP-2研究试验人群中结直肠癌及其他林奇综合征相关肿瘤发病率的长期影响。RS对结直肠癌发病率没有影响，但它减少了其他林奇综合征相关肿瘤的数量，主要是由上消化道癌症所致。尽管该研究存在与二次分析相关的局限性，但它填补了非结直肠林奇综合征相关肿瘤癌症拦截领域的一个重要空白，应为未来林奇综合征中RS的试验奠定基础。见相关文章，第623页。
