Belladelli Federico, Chen Tony, Basran Satvir, Greenberg Daniel R, Del Giudice Francesco, Mulloy Evan, Chen Che-Hong, Cheng Yu-Sheng, Salonia Andrea, Eisenberg Michael L
Division of Experimental Oncology/Unit of Urology; URI; IRCCS Ospedale San Raffaele, Milan, Italy.
School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
World J Mens Health. 2023 Jul;41(3):623-630. doi: 10.5534/wjmh.220106. Epub 2022 Aug 29.
Medicinal and recreational cannabis use has grown exponentially, however, its effect on testicular function and spermatogenesis remains uncertain. The aim of this study was to evaluate the association between cannabis use and semen parameters in a cohort of Asian-American men with unknown fertility.
Asian men were recruited to complete an online survey and submit a semen sample. Semen analysis, demographic data, lifestyle factors, and cannabis use habits were collected. Linear and logistic regression analyses were used to determine.
Among the 112 men included in this study, 51 used cannabis at least once in their lifetime, 30 men used cannabis at least once in the last 12 months, and 26 men used cannabis at least once in the last 30 days. Adjusted linear regression analyses identified an association between cannabis use in the previous 30 days and worse sperm morphology (β: -0.45, p=0.025) and sperm motility (β: -1.64, p=0.016). However, when stratifying by subfertile semen quality (, WHO criteria), no association was identified between semen quality and cannabis use. Lower sperm morphology and motility are partially associated with recent cannabis use, while all other semen parameters are not.
We did not observe any consistent associations between cannabis use on any semen parameters in Asian-American men. Further studies within the field are needed to explore racial and ethnic differences in semen quality and lifestyle factors.
药用和消遣性大麻的使用呈指数级增长，然而，其对睾丸功能和精子发生的影响仍不确定。本研究的目的是评估在一群生育能力不明的亚裔美国男性中，大麻使用与精液参数之间的关联。
招募亚洲男性完成一项在线调查并提交一份精液样本。收集精液分析、人口统计学数据、生活方式因素和大麻使用习惯。采用线性和逻辑回归分析来确定。
在本研究纳入的112名男性中，51人一生中至少使用过一次大麻，30人在过去12个月中至少使用过一次大麻，26人在过去30天中至少使用过一次大麻。调整后的线性回归分析发现，过去30天内使用大麻与较差的精子形态（β：-0.45，p=0.025）和精子活力（β：-1.64，p=0.016）之间存在关联。然而，根据亚生育精液质量（世界卫生组织标准）进行分层时，未发现精液质量与大麻使用之间存在关联。较低的精子形态和活力部分与近期使用大麻有关，而所有其他精液参数则无关。
我们未观察到亚裔美国男性中使用大麻与任何精液参数之间存在任何一致的关联。该领域需要进一步研究以探索精液质量和生活方式因素中的种族和民族差异。
