First Department of Surgery, Yamagata University Faculty of Medicine.
Global Center of Excellence Program Study Group, Yamagata University Faculty of Medicine.
J Nutr Sci Vitaminol (Tokyo). 2022;68(4):270-275. doi: 10.3177/jnsv.68.270.
The element magnesium (Mg) is involved in various metabolic reactions within the human body, and its deficiency is considered a risk factor for several diseases. In this study, we investigated the relationship between serum Mg levels and mortality in a community-based population. We prospectively assessed the association between serum Mg levels at enrollment and all-cause mortality in 1,314 participants who underwent a community health examination. The mean serum Mg level was 2.4 (±0.2) mg/dL. Patients with serum Mg levels ≤2.3 mg/dL constituted the low Mg group, while those with serum Mg ≥2.4 mg/dL constituted the high Mg group. Ninety-three (7.1%) patients died during the 10-y follow-up period. Kaplan-Meier analysis revealed that all-cause mortality was significantly higher in the low Mg group (log-rank p<0.05). Cox proportional hazards analysis revealed a significant association in the unadjusted model (hazard ratio [HR] 1.72, 95% confidence intervals [CI] 1.14-2.58, p<0.01) and in the fully adjusted model (HR 1.73, 95% CI 1.09-2.76, p<0.05). This association was particularly strong in males (HR 2.08, 95% CI 1.19-3.63, p<0.05). Low serum Mg levels were significantly associated with the risk of all-cause mortality among males in a community-based Japanese population.
镁（Mg）是人体内各种代谢反应所必需的元素，其缺乏被认为是多种疾病的危险因素。本研究旨在探讨社区人群血清镁水平与死亡率之间的关系。我们前瞻性评估了 1314 名接受社区健康检查的参与者在入组时的血清镁水平与全因死亡率之间的关系。平均血清镁水平为 2.4（±0.2）mg/dL。血清镁水平≤2.3mg/dL 的患者为低镁组，血清镁水平≥2.4mg/dL 的患者为高镁组。在 10 年的随访期间，有 93（7.1%）名患者死亡。Kaplan-Meier 分析显示，低镁组的全因死亡率显著更高（log-rank p<0.05）。Cox 比例风险分析显示，在未调整模型中存在显著相关性（风险比[HR]1.72，95%置信区间[CI]1.14-2.58，p<0.01），在完全调整模型中也存在显著相关性（HR 1.73，95%CI 1.09-2.76，p<0.05）。这种相关性在男性中尤为明显（HR 2.08，95%CI 1.19-3.63，p<0.05）。在日本社区人群中，低血清镁水平与男性全因死亡率的风险显著相关。
