Li Ge, Tataka Yusei, Kamemoto Kayoko, Wen Haixin, Yamanaka Kazuna, Nagayama Chihiro, Miyashita Masashi
Graduate School of Sport Sciences, Waseda University, Saitama 359-1192, Japan.
Waseda Institute for Sport Sciences, Waseda University, Saitama 359-1192, Japan.
Endocr J. 2022 Dec 28;69(12):1395-1405. doi: 10.1507/endocrj.EJ22-0150. Epub 2022 Sep 1.
Ample evidence supports the notion that an acute bout of aerobic exercise and meal consumption reduces acylated ghrelin concentration. However, the mechanisms by which this exercise- and meal-induced suppression of acylated ghrelin occurs in humans is unknown. This study aimed to examine the concentration of butyrylcholinesterase (BChE), an enzyme responsible for hydrolysing ghrelin and other appetite-related hormones in response to a single bout of running and a standardised meal in young, healthy men. Thirty-three men (aged 23 ± 2 years, mean ± standard deviation) underwent two (exercise and meal conditions) 2-h laboratory-based experiments. In the exercise condition, all participants ran for 30 min at 70% of the maximum oxygen uptake (0930-1000) and rested until 1130. In the meal condition, participants reported to the laboratory at 0930 and rested until 1000. Subsequently, they consumed a standardised meal (1000-1015) and rested until 1130. Blood samples were collected at baseline (0930), 1000, 1030, 1100 and 1130. BChE concentration was not altered in both the exercise and meal conditions (p > 0.05). However, acylated ghrelin was suppressed after exercise (p < 0.05) and meal consumption (p < 0.05). There was no association between the change in BChE concentration and the change in acylated ghrelin before and after exercise (p = 0.571). Although des-acylated ghrelin concentration did not change during exercise (p > 0.05), it decreased after meal consumption (p < 0.05). These findings suggest that BChE may not be involved in the suppression of acylated ghrelin after exercise and meal consumption.
大量证据支持这样一种观点，即一次急性有氧运动和进餐会降低酰基化胃饥饿素浓度。然而，在人类中，这种运动和进餐诱导的酰基化胃饥饿素抑制发生的机制尚不清楚。本研究旨在检测丁酰胆碱酯酶（BChE）的浓度，该酶负责在年轻健康男性进行单次跑步和标准化进餐后水解胃饥饿素及其他与食欲相关的激素。33名男性（年龄23±2岁，均值±标准差）进行了两项（运动和进餐条件）基于实验室的2小时实验。在运动条件下，所有参与者在最大摄氧量的70%强度下跑30分钟（09:30 - 10:00），然后休息至11:30。在进餐条件下，参与者于09:30到达实验室并休息至10:00。随后，他们食用标准化餐食（10:00 - 10:15），并休息至11:30。在基线（09:30）、10:00、10:30、11:00和11:30采集血样。在运动和进餐条件下，BChE浓度均未改变（p>0.05）。然而，运动后（p<0.05）和进餐后（p<0.05）酰基化胃饥饿素受到抑制。运动前后BChE浓度变化与酰基化胃饥饿素变化之间无关联（p = 0.571）。尽管去酰基化胃饥饿素浓度在运动期间未改变（p>0.05），但进餐后降低（p<0.05）。这些发现表明，BChE可能不参与运动和进餐后酰基化胃饥饿素的抑制过程。
