Department of Chemistry, Indian Institute of Technology Madras, Chennai - 600036, India.
Chem Commun (Camb). 2022 Sep 20;58(75):10536-10539. doi: 10.1039/d2cc03719j.
A general and efficient Cp*Co-catalyzed C2-alkylation of -pyridylindoles has been achieved utilizing cyclopropanols as an alkylating reagent. Employing the developed method, diverse C2-alkylated indoles were accomplished in good yield. Additionally, the synthesized C2-alkylated indoles were utilized for the construction of tetrahydrocyclopenta-[]indole, and 2-(3,3-arylallyl)-1-(pyridin-2-yl)-1-indoles. Additionally, a plausible mechanism was also proposed.
利用环丙醇作为烷基化试剂，实现了 Cp*Co 催化的通用、高效的 -吡啶基吲哚的 C2-烷基化。采用所开发的方法，以良好的收率得到了各种 C2-烷基化吲哚。此外，所合成的 C2-烷基化吲哚还用于构建四氢环戊并[]吲哚和 2-(3,3-芳基烯丙基)-1-(吡啶-2-基)-1-吲哚。此外，还提出了一个可能的机制。
