State Key Laboratory Base of Eco-Chemical Engineering College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, 266042, P. R. China.
Chem Asian J. 2022 Nov 2;17(21):e202200818. doi: 10.1002/asia.202200818. Epub 2022 Sep 20.
During the past decades, in synthetic organic chemistry, directing-group-assisted C-H functionalization is found to be a key tool for the expedient and site-selective construction of C-C and hybrid bonds. Among C-H functionalization of ferrocene derivatives, the directed group strategy is undoubtedly the most commonly used method. Compared to the other directing groups, ferrocene amides can be synthesized easily and are now recognized as one of the most efficient tools for the selective functionalization of certain positions because its metal centre permits fine, tuneable and reversible coordination. The family of amide directing groups mainly comprises monodentate and bidentate directing groups, which are categorized on the basis of coordination sites. In this review, various C-H bond functionalization reactions of ferrocene using amide directing groups are broadly discussed.
在过去几十年中，在合成有机化学中，导向基团辅助的 C-H 功能化被发现是一种用于快速和选择性构建 C-C 和杂化键的关键工具。在二茂铁衍生物的 C-H 功能化中，导向基团策略无疑是最常用的方法。与其他导向基团相比，二茂铁酰胺易于合成，现在被认为是选择性官能化某些位置的最有效工具之一，因为其金属中心允许精细、可调谐和可逆的配位。酰胺导向基团家族主要包括单齿和双齿导向基团，它们根据配位位点进行分类。在这篇综述中，广泛讨论了使用酰胺导向基团的二茂铁的各种 C-H 键功能化反应。
